Subtypes of presynaptic auto- and hetero-α2-adrenoceptors expressed on axon terminals and on locus ceruleus
| Subtype | Reference | ||
|---|---|---|---|
| Heteroceptor | |||
| Cholinergic | |||
| Ileum (guinea-pig Auerbach plexus) | α2A | Blandizzi et al., 1991, 1993 | |
| Serotonergic | |||
| Synaptosome (rat brain) | α2A | Gobbi et al., 1990 | |
| Autoreceptor | |||
| Noradrenergic | |||
| Ileum (guinea pig) | α2B | Blandizzi et al., 1993 | |
| Thymus (rat) | α2B | Haskó et al., 1995 | |
| Spleen (rat) | α2B | Elenkov and Vizi, 1991 | |
| Heart (guinea pig) | α2B | Vizi ES (unpublished) | |
| (human) | α2B | Vizi and Lendvai, 1997; Sato et al., 1999 | |
| Hippocampus (rat) | α2A | Kiss et al., 1995 | |
| Hypothalamus (rat) | α2A | Karkanias and Etgen, 1993; Sperlágh et al., 1998 | |
| Cortex (rat) | α2A | Trendelenburg et al., 1993, 1994 | |
| (human) | α2A | Raiteri et al., 1992; Sastre and Garcia-Sevilla, 1994a,b; Garcia-Sevilla et al., 1999 | |
| Spinal cord (rat) | α2A | Umeda et al., 1997 | |
| (human) | α2A | Lawhead et al., 1992 | |
| Synaptosome (rat brain; rat) | α2A | Gobbi et al., 1990 | |
| Locus ceruleus (rat) | α2A | Mateo et al., 1998 | |
| Arteries (human gastric and ilecolic) | α2A | Guimaraes et al., 1998 | |
For expression of mRNA of α2-adrenoceptor subtypes, seeWinzer-Sershan et al. (1997a,b).