Table 5

Distribution of the AT2 receptor in the brain—effect of age

2-wk-old8-wk-old
fmol/mg protein
(mean ± S.E.M.)
Regions containing only the AT2 receptor
 Persistent AT2 receptor with age
  Lateral septal nucleus58  ± 618  ± 3
  Ventral thalamic nuclei101  ± 824  ± 3
  Mediodorsal thalamic nucleus165  ± 1138  ± 13
  Locus ceruleus289  ± 1998  ± 13
  Principal sensory trigeminal nucleus75  ± 615  ± 4
  Parasolitary nucleus220  ± 1557  ± 14
  Inferior olive1328  ± 61181  ± 32
  Medial amygdaloid nucleus159  ± 894  ± 9
  Medial geniculate nucleus338  ± 2471  ± 6
 Transient expression of the AT2 receptor
  Anterior pretectal nucleus53  ± 8N.D.
  Nucleus of the optic tract101  ± 13N.D.
  Ventral tegmental area101  ± 11N.D.
  Posteodorsal tegmental nucleus110  ± 21N.D.
  Hypoglossal nucleus141  ± 11N.D.
  Central medial and paracentral thalamic nucleus202  ± 14N.D.
  Laterodorsal thalamic nucleus110  ± 10N.D.
  Oculomotor nucleus98  ± 13N.D.
Regions containing both AT1 and AT2 receptors
 Persistent AT2 receptor with age
  Superior collicus145  ± 565  ± 8
  Cingulate cortex19  ± 48  ± 4
 Transient expression of the AT2 receptor
  Cerebellar cortex59  ± 6N.D.
  • N.D., not determined.