Table 8

Binding constants for AT4 receptors in various species and tissues

SpeciesTissueKdBmax
nM fmol/mg protein
RabbitHeart1.75  ± a58-a 731  ± 163
RatHeart3.3  ± 1.1320  ± 66
BovineAdrenals0.74  ± 0.143820  ± 1120
Guinea pigHeart1.33  ± 0.02144  ± 19
Guinea pigHippocampus1.29  ± 0.18499  ± 62
BovineVascular smooth muscle1.85  ± 0.45960  ± 100
BovineVascular smooth muscle0.70  ± 1.0476  ± 57
Guinea pigVascular smooth muscle0.40  ± 0.091040  ± 239
MonkeyKidney1.5  ± 0.311000  ± 212
Guinea pigColon0.84  ± 0.08659  ± 75
HumanProstate0.60  ± 0.151399  ± 152
  • 8-a  Mean ± S.D.,n = 2–4. Study performed with 125I-Ang IV.