Table 5

Presynaptic angiotensin receptors mediating modulation of sympathetic transmitter release

SpeciesTissueParameter DeterminedEffect of Receptor ActivationReceptor SubtypeReference
MouseAtriumNA releaseFacilitationAT Cox et al., 2000
RatTail arteryNA releaseFacilitationAT Mota et al., 2000
RatAtriumNA releaseFacilitationAT1 Shetty and DelGrande, 2000
Guinea pigHeartNA releaseFacilitationAT1 Maruyama et al., 1999
MouseAtrium and spleenNA releaseFacilitationAT1 Cox et al., 1999
DogMesenteric artery and pulmonary arteryNA releaseFacilitationNon-AT1 and non-AT2 Guimaraes et al., 1998b
RabbitAortaNA releaseFacilitationAT Storgaard and Nedergaard, 1997
Guinea pigMesenteric arteryejpFacilitationAT1 Onaka et al., 1997
RatHeartNA releaseFacilitationNon-AT1and non-AT2 Moura et al., 1997
HumanAtrial appendagesNA releaseFacilitationAT Abadie et al., 1996
RatCaudal arteryNA release and neurogenic vasoconstrictionFacilitationAT1B Cox et al., 1996a
RatCaudal arteryNA release and neurogenic vasoconstrictionFacilitationAT1B Cox et al., 1996b
HumanAtriumNA releaseFacilitationAT Munch et al., 1996
RatAtriumNA releaseFacilitationAT1 Foucart et al., 1996
HumanKidneyNA releaseFacilitationAT1 Rump et al., 1995
RabbitPulmonary arteryNA release and neurogenic contractionInhibitionAT1B Sim and Soh, 1995
RatCaudal arteryNA releaseFacilitationAT Cox et al., 1995
Vas deferensNeurogenic contraction
Guinea pigVas deferensNA release and ATP release and neurogenic contractionFacilitationAT Driessen and Starke, 1994
RatAtriumNA releaseFacilitationAT1 and AT2 Gironacci et al., 1994
HumanAtriumNA releaseFacilitationAT1 Rump et al., 1994
RatAdipose tissueNA releaseFacilitationAT Cassis and Dwoskin, 1994

  • NA, noradrenaline; ejp, excitatory junction potential.