Antagonistic ligands | ω-3 and ω-6 polyunsaturated fatty acyl-CoAs | | Unknown |
Hertz et al., 1998
|
| (C18:3, ω-3)-CoA | | Lowers affinity of the HNF-4α dimer to its cognate enhancer |
| Saturated (C18:0)-CoA | | Lowers affinity of the HNF-4α dimer to its cognate enhancer |
| | | Leads to decreased HNF-4α dimerization |
Repressors | SHP | AF-2 | Competition with coactivators for the AF-2 binding domain |
Lee et al., 2000
|
| | AF-2 | Direct inhibition after binding to the AF-2 domain through a SHP repressor domain (unknown mechanism) |
| COUP-TFs | No | Competition with HNF-4α for binding to cis-acting DNA sites of many regulatory regions |
Kimura et al., 1993; Ktistaki and Talianidis, 1997
|
| HNF-1α | AF-2 | Binding to the AF-2 domain, probably competing with coactivators |