Table 4

Amino acid sequence variations in CB₁ among 60 placental mammals

Position^4-a	Variants^4-bNumber/Total	Consensus	Variants^4-b	Domain
53	9 /59	F	Y	Amino terminal
66	2 /59	D	E	Amino terminal
67	25 /29	N	S,T,H	Amino terminal
68	22 /59	P	A,S,T	Amino terminal
69	4 /59	Q	P	Amino terminal
71	4 /59	V	G,I,A	Amino terminal
73	12 /59	A	G,V,S	Amino terminal
74	4 /59	D	G,V,A	Amino terminal
75	20 /59	—	P,D	Amino terminal
76	20 /59	Q	G,T,A,—	Amino terminal
77	15 /58	V	L,A,T,G,I	Amino terminal
79	21 /59	I	L,M,V	Amino terminal
83	2 /59	Y	F,L	Amino terminal
90	12 /60	F	Y	Amino terminal
94	21 /60	E	D,G,—	Amino terminal
106	4 /60	M	I	Amino terminal
111	4 /60	I	V	Amino terminal
176	4 /60	V	I	Extracellular end of TM1
187	5 /60	P	R,H	Extracellular, adjacent to TM3
259	4 /60	K	E	Extracellular, adjacent to TM4
262	6 /60	Q	K,R	Extracellular, between TM4 and TM5
271	4 /60	L	H	Extracellular, between TM4 and TM5
286	2 /54	T	S	TM5
312	2 /53	R	P	Intracellular, between TM5 and TM6

TM, transmembrane.
↵4-a Numbering based on rat (or mouse) sequence.
↵4-b Variant sequences listed only for positions at which more than one sequence deviates from the consensus.