Table 3

Localization and potential roles of the human proteinase-activated receptors

Tissue distribution3-a (Northern blot analysis)Brain, lung, heart, stomach, colon, kidney, testisProstate, small intestine, colon, liver, kidney, pancreas, tracheaHeart, kidney, pancreas, thymus, small intestine, stomach, lymph node, tracheaLung, pancreas, thyroid, testis, small intestine, placenta, skeletal muscle, lymph node, adrenal gland, prostate, uterus, colon
Cellular expressionPlatelets, endothelium, vascular smooth muscle, leukocytes, GI tract epithelium, fibroblasts, neurons, mast cellsEndothelium, leukocytes, GI tract epithelium and lung, airway and vascular smooth muscle, neurons, mast cells, keratinocytes, lung fibroblasts, renal tubular cellsAirway smooth muscle, plateletsPlatelets, megakaryocytes
Known physiological rolePlatelet activationPlatelet activation
Potential physiological rolesPro-inflammatory, embryonic development, regulation of vascular tonePro-inflammatory, mediator of nocioception, airway protection, regulation of vascular toneCofactor for PAR4 Platelet activation
  • GI, gastrointestinal.

  • ↵3-a  Information for PAR2, PAR3, and PAR4 is provided for human tissues; for PAR1, distribution is recorded in rat tissues, for which more extensive data are available than in human tissues.