Table 4

Pharmacological profile of human receptors in the presence and absence of human RAMPs

Receptor	hCT	sCT	rAMY	hαCGRP	Cell	References
hCT_(b)receptor	9.45/6.89	10.56/6.93	6.58	6.77	COS-7	Tilakaratne et al., 2000
	10.93/6.78	11.06/8.12	10.0/5.65	11.08/5.77	CHO-P	Tilakaratne et al., 2000
hCT_(b)receptor/hRAMP1	6.94	10.98/9.29	10.95/8.43	9.93/7.94	COS-7	Tilakaratne et al., 2000
	9.89/6.95	11.2/6.41	11.29/8.66	11.89/8.64	CHO-P	Tilakaratne et al., 2000
hCT_(b)receptor/hRAMP2	7.95	11.06/9.33	10.67/8.23	10.87/7.72	COS-7	Tilakaratne et al., 2000
	9.63/6.42	11.83/8.83	10.65/7.59	10.96/7.7	CHO-P	Tilakaratne et al., 2000
hCT_(b)receptor/hRAMP3	6.87	11.06/9.16	11.03/8.19	8.9/7.1	COS-7	Tilakaratne et al., 2000
	10.19/5.95	11.53/8.89	11.55/8.2	10.1/6.9	CHO-P	Tilakaratne et al., 2000
hCT_(a)receptor	7.81	9.03	6.27	>6	COS-7	Zumpe et al., 1999
			6.3	>6	RAEC	Muff et al., 1999
	11.12/6.45	11.96/8.08	6.07	9.94/5.78	CHO-P	Tilakaratne et al., 2000
hCT_(a)receptor/hRAMP1	6.92	9.05	8.27	7.87	COS-7	Christopoulos et al., 1999
	7.53	9.51	8.1	7.67	COS-7	Zumpe et al., 1999
			8.5	7.85	RAEC	Muff et al., 1999
	9.79/5.97	12.19/9.00	11.9/8.03	8.9/6.03	CHO-P	Tilakaratne et al., 2000
hCT_(a)receptor/hRAMP2	8.08	9.89	7.82	5.86	COS-7	Zumpe et al., 1999
	No evidence of coupling; wild-type phenotype		RAEC	Muff et al., 1999
	8.94/5.92	12.19/8.54	8.13	7.64	CHO-P	Tilakaratne et al., 2000
hCT_(a)receptor/hRAMP3	7.71	9.68	8.2	6.82	COS-7	Zumpe et al., 1999
			8.40	6.59	RAEC	Muff et al., 1999
	11.11/6.02	12.12/8.29	11.7/7.78	10.96/6.79	CHO-P	Tilakaratne et al., 2000

Values represent pIC₅₀ values obtained against¹²⁵I-AMY or ¹²⁵I-sCT. Where two sites were detected, the sites highlighted in bold were present at >60%.