Inhibitory potency of the noncompetitive antagonist, SCH-202676, on the orthosteric binding of different Class I GPCRs
| Receptor | Radioligand | IC50 |
|---|---|---|
| μm | ||
| δ-Opioid | [3H]Diprenorphine | 0.3 |
| κ-Opioid | [3H]Diprenorphine | 1.7 |
| μ-Opioid | [3H]Diprenorphine | 1.8 |
| M1muscarinic | [3H]N-methylscopolamine | 0.4 |
| M2muscarinic | [3H]N-methylscopolamine | 0.4 |
| α2A-Adrenergic | [3H]Yohimbine | 0.5 |
| β1-Adrenergic | [125I]Iodocyanopindolol | 1.2 |
| D1 dopamine | [3H]SCH-23390 | 0.1 |
| D2dopamine | [3H]Methylspiperone | 0.1 |
Adapted from Fawzi et al., 2001.