Inhibitory potency of the noncompetitive antagonist, SCH-202676, on the orthosteric binding of different Class I GPCRs
Receptor | Radioligand | IC50 |
---|---|---|
μm | ||
δ-Opioid | [3H]Diprenorphine | 0.3 |
κ-Opioid | [3H]Diprenorphine | 1.7 |
μ-Opioid | [3H]Diprenorphine | 1.8 |
M1muscarinic | [3H]N-methylscopolamine | 0.4 |
M2muscarinic | [3H]N-methylscopolamine | 0.4 |
α2A-Adrenergic | [3H]Yohimbine | 0.5 |
β1-Adrenergic | [125I]Iodocyanopindolol | 1.2 |
D1 dopamine | [3H]SCH-23390 | 0.1 |
D2dopamine | [3H]Methylspiperone | 0.1 |
Adapted from Fawzi et al., 2001.