Table 9

Ligand-binding properties of selected opioid ligands for the κ–δ heterodimer

LigandKI (nM)
κδκ–δ
U69593 14.4>1000>1000
DPDPE>100021.8>1000
U69593 (+ 10 μM DPDPE)14.4—9-a 9.2
DPDPE (+ 10 μMU69593)—9-a 24.820.0

  • ↵9-a  Not tested.

  • Data from Jordan and Devi, 1999.