Major biological actions of leukotrienes and lipoxins
| Actions | References |
|---|---|
| Dihydroxy-leukotrienes (LTB4) | |
| Leukocyte activation | Bray et al., 1980;Ford-Hutchinson et al., 1980; Goetzl and Picket, 1980; Serhan et al., 1982 |
| Cytokine secretion | Luscinskas et al., 1990;Rola-Pleszczynski et al., 1993 |
| Nuclear transcription (PPARα) | Devchand et al., 1996 |
| IgE synthesis | Odlander et al., 1988; Yamaoki et al., 1994 |
| Cysteinyl-leukotrienes (LTC4, LTD4, LTE4) | |
| Bronchospasm | Drazen et al., 1980;Weiss et al., 1982; Barnes et al., 1984;Jones et al., 1985; Davidson et al., 1987; Smith et al., 1993 |
| Plasma exudation | Woodward et al., 1983; Evans et al., 1985; Obata et al., 1992 |
| Vasoconstriction | Smedegard et al., 1982;Filep et al., 1985; Fiedler and Abram, 1987; Garcia et al., 1987; Evans et al., 1989 |
| Vasodilation | Secrest et al., 1985;Sakuma and Levi, 1988; Lawson et al., 1989; Pawloski and Chapwick, 1993b; Ortiz et al., 1995 |
| Eosinophil recruitment | Foster and Chan, 1991; Laitinen et al., 1993; Smith et al., 1993; Spada et al., 1994;Underwood et al., 1996 |
| Cardiodepression | Levi et al., 1980; Burke et al., 1982; Letts and Piper, 1983;Bittl et al., 1985; Roth et al., 1985 |
| Smooth muscle proliferation | Wang et al., 1993;Panettieri et al., 1998 |
| Mucus secretion | Shelhamer et al., 1980; Coles et al., 1983; Labat et al., 1999 |
| Lipoxins ( LX ) and Aspirin-Triggered Lipoxin Analogs (ATLa) | |
| Regulation of cellular function | Fiore et al., 1994; Chiang et al., 2000; Kang et al., 2000; Gronert et al., 2001 |
| Inhibition of PMN-mediated inflammation in skin, lung and kidney | Badr et al., 1989; Takano et al., 1998; Clish et al., 1999; Chiang et al., 2000; Godson and Brady, 2000 |
| Protection in reperfusion injury | Chiang et al., 1999 |
| Enhancement of macrophage phagocytosis of leukocytes | Godson and Brady, 2000 |
| Redirection of chemokine, cytokine expression and gene regulation | Gewirtz et al., 1998; Hachicha et al., 1999; Sodin-Semrl et al., 2000; Qui et al., 2001 |
| Enhancement of clearance and accelerate resolution of pulmonary edema | Bandeira-Melo et al., 2000 |
| Anti-angiogenic properties | Fierro and Serhan, 2001 |
| Reduction of COX-2 traffic in pain responses | Serhan et al., 2001 |
| Inhibition of cell proliferation | Clària et al., 1996 |