Table 2

Human cloned leukotriene receptors2-a

IUPHAR code2.1 :BLT :1 :BLT12.1 :BLT :2 :BLT22.1 :CLT :1 :CLT12.1 :CLT :2 :CLT22. :ALX
Alternate namesLeukotriene B4 Leukotriene B4 Leukotriene D4/E4 2-b Leukotriene C4 2-b Lipoxin A4/FPRL-1
Amino acid composition352 (h)358 (h)337 (h)346 (h)351
Selective ligandNoneNoneNoneNoneNone
Non-selective ligandLTB4 LTB4 LTC4/LTD4/LTE4 LTC4/LTD4/LTE4 LXA4/fMLP
Primary coupling2-c G16, Gi2 Gq-like, Gi-like, Gz-likeGαq Gαq Gi, Gq
Primary expressionLeukocytes, thymus, spleenOvary, liver, leukocytes, ubiquitousSmooth muscle (lung, intestine), spleen, peripheral blood leukocytesHeart, spleen, peripheral blood leukocytes, adrenal medulla, brainLung, peripheral blood leukocytes, spleen
Accession number (Swiss-Prot) Q15722(h)Q9NPC1 (h)Q9Y271 (h)Q9NS75 (h) P25090 (h)

Data are from the following references: Fiore et al., 1992, 1994; Perez et al., 1992; Maddox et al., 1997; Takano et al., 1997; Yokomizo et al., 1997;Lynch et al., 1999; Sarau et al., 1999;Heise et al., 2000; Nothacker et al., 2000; Takasaki et al., 2000; Figueroa et al., 2001.

    • 2-a  The reader is referred to the text for the mouse cloned receptors.

    • 2-b  No longer acceptable since all ligands activate the same receptor in isolated human bronchi.

    • 2-c  These observations should be considered with some reserve since there is marked variation between the types of G-proteins present in cells (see text). (h) indicates human.