Table 5
CysLT1-selective and nonselective antagonists and structures
| Glossary of chemical names and codes of several cysteinyl-leukotriene antagonists: | ||
| BAYu9773 | 6-(4′-Carboxyphenylthio)-5(S)-hydroxy-7(E), 9(E), 11(Z), 14(Z)-eicosatetraenoic acid | |
| BAYx7195 | (4S)-(4-Carboxyphenylthio)-7-[4-(4-phenoxybutoxy)-phenyl]-hept-5-(Z)-enoic acid | |
| CGS23131 | 5-(3-Carboxybenzoyl)-2-((6-(4-methoxyphenyl)-5-hexenyl)oxy)benzenepropanoic acid | |
| CGS25019C | 4-(5-[4-{Aminoiminomethyl} phenoxy]-pentoxy)-3-methoxy-N,N-bis(1-methylethyl)-benzamide-(Z)-2-butenedioate | |
| CP195543 | (+)-2-(3-Benzyl-4-hydroxychroman-7-yl)-4-trifluoromethylbenzoic acid | |
| FPL55712 | Sodium 7-(3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydroxypropoxy)-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylate | |
| ICI198615 | (1-[2-Methoxy-4-{([phenylsulfonylamino]carbonyl)phenyl} methyl]-1H-indazol-6-yl) carbamic acid cyclopentyl ester | |
| ICI204219 | Zafirlukast (Accolate™) | 4-(5-Cyclopentyloxy-carbonyl-amino-1-methyl-indol-3-ylmethyl)-3-methoxy-N-O-tolylsufonylbanzamide |
| LY170680 | Sulukast | 5-(3-[2(R)-Carboxyethylthio)-1(S)-hydroxypentadeca-3(E),5(Z)-diethyl]phenyl-1H-tetrazole |
| LY171883 | Tomelukast | 1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone |
| LY223982 | (E)-5-(3-Carboxybenzoyl)-2-([6-{4-methoxyphenyl}-5-hexenyl]oxy)benzenepropanoic acid | |
| LY293111 | (2-[2-Propyl-3-{2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenyl}propoxy]phenoxy)benzoic acid | |
| MK476 | Montelukast (Singulair™) | (1-[{(R)-(-[2-{7-Chloro-2-quinolinyl}-(E)-ethenyl]phenyl)(3-2-[1-hydroxy-1-methylethyl]phenyl)propyl}thio]methyl)cyclopropane acetic acid sodium |
| MK571 | [3-{2-(7-Chloro-2-quinolinyl)ethenyl} phenyl][{3-(dimethylamino-3-oxopropyl)thio}methyl]thio propanoic acid | |
| SB209247 | (E-3-(6-[{(2,6-Dichlorophenyl)-thio}methyl]-3-[2-phenylethoxy]-2-pyridinyl)-2-propenoic acid | |
| ONO1078 | Pranlukast (Onon™) | 4-Oxo-8-[p-(4-phenylbutyloxy)benzoylamino]-2-(tetrazol-5-yl)-4H-1-benzopyran hemihydrate |
| SB205312 | 4-Oxo-8-[p-(4-phenylbutyloxy)benzoylamino]-2-(tetrazol-5-yl)-4H-1-benzopyran hemihydrate | |
| SC53228 | ((+)-(S)-7-[3-{2-Cyclopropylmethyl}-3-methoxy-4-{(methylamino)carbonyl} phenoxy]propoxy)-3,4-dihydro-8-propyl-2H-1-benzopyran-2-propanoic acid | |
| SKF104353 | Pobilukast | 2S-Hydroxy-3R-(2-carboxyethylthio)-3-(2-[8-phenyloctyl]phenyl)-propanoate |
| SR2640 | 2-(3-[2-Quinolylmethoxy]phenylamino)benzoic acid | |
| WY48252 | N-(3-[2-Quinolinylmethoxy]phenyl)-trifluoromethanesulphonamide |