In vivo evidence of amyloidogenic CT fragment generation
| Tissue | Source | Reference |
|---|---|---|
| Human lymphoblastoid cells | Normal and FAD patients | Matsumoto and Fujiwara, 1991,1993 |
| Human platelets and megakaryocytes | Down syndrome | Matsumoto and Matsumoto, 1994 |
| Human brains | Normal and FAD patients | Gardella et al., 1992; Ghiso et al., 1992; Kametani et al., 1994 |
| Microvessels and leptomeningeal vessels | ||
| Senile plaques Paired helical flaments Cerebral gray matter | Normal and AD patients | Nordstedt et al., 1991; Estus et al., 1992; Ghiso et al., 1992; Tamaoka et al., 1992 |
| White matter | AD patients | Selkoe et al., 1988 |
| Optic nerve | AD patients | Caputo et al., 1992 |
| Human brain | Aged individuals | Nordstedt et al., 1991 |
| Down syndrome patients | Tokuda et al., 1995 | |
| Healthy individuals | Amaratunga and Fine, 1995 | |
| Healthy individuals | Golde et al., 1992 | |
| Neurites of amygdala and hippocampus | Down syndrome patients | Estus et al., 1992; Kametani et al., 1994 |
| Transgenic mice | AD patients | Daly et al., 1998 |
| CA 2/3 region of hippocampus of CT transgenic mice | Kammesheidt et al., 1992; Oster-Granite et al., 1996 | |
| Brain of transgenic mice with β-APP-containing native and genetic mutations | Transgenic mice carrying CT100 | Howland et al., 1995;Araki et al., 1995; Nalbantoglu et al., 1997; Sato et al., 1997 |