Summary of various effects of Aβ and CT
| Aβ | CTF | Reference | |
|---|---|---|---|
| Neurotoxicity | |||
| Cultured cells | + | +10 | Kim and Suh, 1996; Marcon et al., 1999; Lee et al., 2000a |
| in vivo i.c.v. | + | +++ + | Song et al., 1998; Choi et al., 2001 |
| Transgenic mice Neuritic plaques | +++ | +++ | Kammesheidt et al., 1992; Nalbantoglu et al., 1997; Sato et al., 1997 |
| Channel effect | |||
| Xenopusoocytes | − | +++ | Fraser et al., 1996;1997; Kim et al., 2002 |
| Purkinje cells | − | +++ | Hartell and Suh, 2000 |
| Lipid bilayer | + | ++ | Arispe et al., 1993; Kim et al., 1999 |
| Intracellular Ca2+ | + | +++ | Kim et al., 1999, 2002;McKeon-O'Malley et al., 1999 |
| LTP hippocampus | + | +++ | Cullen et al., 1997;Nalbautoglu et al., 1997; Kim et al., 2001 |
| Learning and memory impairment | + | +++ | Kammesheidt et al., 1992;Nalbantoglu et al., 1997; Sato et al., 1997; Song et al., 1998; Choi et al., 2001 |
| Cholinergic deficit | + | +++ | Choi et al., 2001 |
| Free radical generation | +++ | − | |
| NO generation | + | +++ | Rah et al., 2001; Bach et al., 2001 |
| MAPK signaling | + | +++ | Rah et al., 2001; Chong et al., 2001; Bach et al., 2001 |
| NF-κB | + | +++ | Rah et al., 2001; Chong et al., 2001; Bach et al., 2001 |
| Nuclear translocation | − | +++ | DeGiorgio et al., 2000;Cao and Sudhof, 2001; Kimberly et al., 2001; Gao and Pimplikar, 2001; Kim et al., 2002 |
| Inflammatory cytokines and chemokines | + | +++ | Rah et al., 2001; Chong et al., 2001 |
| Gliosis and astrocytosis | + | +++ | Song et al., 1998;Rah et al., 2001; Bach et al., 2001 |