Functions of sAPPα
| Cell Type | Function | Reference |
|---|---|---|
| Cortical neurons | Cell survival | Araki et al., 1991 |
| Hippocampal neurons | Protection against excitotoxic, metabolic, and oxidative insults | Barger et al., 1995,1996; Furukawa et al., 1996; Goodman and Mattson, 1994; Mattson et al., 1993 |
| Cortical and hippocampal neurons | Protect neurons against Aβ or CT toxicity | Kihara et al., 1997; Zamani et al., 1997; Seo et al., 2001 |
| CA1 neurons | Protection against ischemic injury or enhance recovery from ischemic injury | Bowes et al., 1994; Smith-Swintosky et al., 1994 |
| PC12 cells | Neurite outgrowth promotion | Milward et al., 1992 |
| Hippocampal neurons | Modulation of excitability | Furukawa et al., 1996 |
| Neocortical cells | Activate phospholipase C/protein kinase C | Ishiguro et al., 1998 |
| Neuroblastoma cells, hippocampal neurons | Induction of neuroprotective κB-dependent transcription | Barger and Mattson, 1996 |
| Hippocampal neurons | Activated K+ channels and reduced [Ca2+]i | Furukawa et al., 1996 |
| Fibroblasts | Induces proliferation | Saitoh et al., 1989 |
| Platelets | Modulates blood coagulation | Smith et al., 1990 |