Factor | Cells | α-Secretase Activity | Reference |
---|---|---|---|
Acetylcholine | PC12 cells | ↑ | Buxbaum et al., 1992; Haring et al., 1995; Nitsch et al., 1992 |
Electrical stimulation | Hippocampus | ↑ | Nitsch et al., 1993 |
Metabotropic glutamate | Hippocampus | ↑ | Lee et al., 1995; Lee and Wurtman, 1997 |
Agonist | HEK293 cells | Nitsch et al., 1997 | |
5-HT2aand 5-HT2c agonist | 3T3 cells | ↑ | Nitsch et al., 1996 |
NGF and EGF | PC12 cells | ↑ | Refolo et al., 1989 |
NGF | Hippocampus | ↑ | Clarris et al., 1994 |
Phorbol esters | PC12 cells | ↑ | Buxbaum et al., 1990,1992; Caporaso et al., 1992 |
cAMP | C6 glioma cells | ↓ | Efthimiopoulos et al., 1996 |
HEK293 cells | ↑ | Marambaud et al., 1998b,1999 |
EGF, epidermal growth factor; 5-HT, 5-hydroxytryptamine.