VIPa | Avidin/biotin | Rat brain | Effective by 65% increase in cerebral blood flow |
Bickel et al., 1993
|
PNA | SA/biotin | Rat brain | 28-fold increased uptake after coupling the OX26-SA |
Pardridge et al., 1995
|
Daunomycin | PEG-liposome | Rat brain | Expanding the loading by using PEG-liposome |
Huwyler et al., 1996
|
BDNF | PEG-SA/biotin | 3T3-TrB cell; rat brain | 2-fold increased uptake compared with small molecule; neuroprotective effect in brain |
Pardridge et al., 1998; Wu and Pardridge, 1999
|
| | Rat brain (MCAO) | Reduce in cortical stroke volume |
Zhang and Pardridge, 2001a,b |
Antisense ODNs, PNA | SA/biotin | Alzeheimer and HIV model; Rat brain | Increased cellular uptake ODNs in vitro; plasma protein inhibited the transport in vivo |
Boado et al., 1998
|
Genes | PEG-liposome | Rat brain | Wide spread gene expression in the central nervous system |
Shi and Pardridge, 2000
|
Antisense 16-mer PNA | Avidin/biotin | Rat brain with tumors | Gene expression in the brain in vivo can be used in antisense imaging |
Shi et al., 2000
|
NGF | Chemically linked | Rat brain | Prevent degeneration of central NGF-responsive neurons |
Kordower et al., 1994
|