Parameter | Total Radioactivity after Oral Administration | Unchanged Drug after Oral Administration | Total Metabolites after Oral Administration |
---|---|---|---|
Male | |||
C_{max} | 43.2 μg/ml | 34.2 μg/ml | 11.3 μg/ml^{c} |
AUC | 540 μg·h/ml | 397 μg eq·h/ml | 143 μg·h/ml^{d} |
Urinary excretion | 57.4%^{a} | 2.1%^{b} | 52.2%^{e} |
Female | |||
C_{max} | 38.7 μg/ml | 36.7 μg/ml | 2.6 μg/ml^{c} |
AUC | 353 μg·h/ml | 326 μg·h/ml | 27 μg·h/ml^{d} |
Urinary excretion | 70.4%^{a} | 39.5%^{b} | 29.9%^{e} |
AUC, area under the curve.
↵ a Oral dose of 20 mg/kg [^{14}C]egualen sodium. All values are means expressed as micrograms of egualen equivalents (adapted from Sato et al., 2000). Values with the same superscript letter are significantly different, p < 0.01