TABLE 6

Gender-related differences in renal clearance of egualen sodium in rats a

Unchanged Drug
ml/min/kg
Male
    Renal clearance 0.009 (0.002)
    Probenecid tx 0.031 (0.005)
    Gonadectomy 0.158 (0.024)
    Probenecid tx after gonadectomy 0.055 (0.004)
    Testosterone tx after gonadectomy 0.004 (0.002)
Female
    Renal clearance 0.193 (0.030)**
    Probenecid tx 0.081 (0.009)
    Gonadectomy 0.272 (0.055)
    Testosterone tx after gonadectomy 0.102 (0.033)
  • ** p < 0.01. tx, treatment

  • a IV infusion: rate = 4 μg/min. Results expressed as mean (S.E.) (adapted from (Sato et al., 2000)