Major drug transporters expressed in intestine, kidney, liver, and brain of human or rat
| Human | Rat | ||
|---|---|---|---|
| Name | Localization | Name | Localization |
| Intestine | |||
| Peptide transporter | |||
| PEPT1 | BBM | PepT1 | BBM |
| Organic anion transporter | |||
| OATP-B | NDa | Oatp3 | BBM |
| OATP-D | ND | ||
| OATP-E | ND | ||
| ASBT | BBM | Asbt | BBM |
| Organic cation transporter | |||
| Oct1 | BLM | ||
| Oct3 | ND | ||
| Octn1 | ND | ||
| Primary active transporter | |||
| MDR1 | BBM | Mdr1 | BBM |
| MRP2 | BBM | Mrp2 | BBM |
| MRP3 | BLM | Mrp3 | BLM |
| BCRP | BBM | ||
| Kidney | |||
| Peptide transporter | |||
| PepT1 | BBM | ||
| PEPT2 | ND | PepT2 | BBM |
| Organic anion transporter | |||
| OAT1 | BLM | Oat1 | BLM |
| OAT3 | BLM | Oat3 | BLM |
| OAT4 | BBM | ||
| Oatp1 | BBM | ||
| Oat-K1 | BBM | ||
| Oat-K1 | ND | ||
| NaPi-1/Npt1 | BBM | ||
| Asbt | BBM | ||
| Organic cation transporter | |||
| Oct1 | BLM | ||
| Oct1A | ND | ||
| OCT2 | BLM | Oct2 | BLM |
| Oct3 | ND | ||
| OCTN1 | ND | Octn1 | BBM |
| OCTN2 | ND | Octn2 | BBM |
| Primary active transporter | |||
| MDR1 | BBM | Mdr1 | BBM |
| MRP2 | BBM | Mrp2 | BBM |
| MRP4 | BBM | Mrp4 | BBM |
| Liver | |||
| Organic anion transporter | |||
| NTCP | SM | Ntcp | SM |
| OATP-C | SM | Oatp1 | SM |
| OATP8 | SM | Oatp2 | SM |
| OATP-B | SM | Oatp4 | SM |
| OAT2 | SM | Oat2 | SM |
| Oat3 | SM | ||
| NaPi-1/Npt1 | SM | ||
| Organic cation transporter | |||
| OCT1 | ND | Oct1 | SM |
| Oct1A | ND | ||
| OCT3 | |||
| Octn1 | ND | ||
| Primary active transporter | |||
| MRP1 | SM | ||
| MRP3 | SM | Mrp3 (EHBR, TR-) | SM |
| MDR1 | CM | Mdr1 | CM |
| MRP2 | CM | Mrp2 | CM |
| BSEP/SPGP | CM | Bsep/Spgp | CM |
| BCRP | CM | ||
| Brain capillary endothelial cells | |||
| Organic anion transporter | |||
| OATP-A | ND | Oat2 | ALM, LM |
| Oat3 | ND | ||
| Organic cation transporter | |||
| Oct2 | ND | ||
| Primary active transporter | |||
| MDR1 | LM | Mdr1 | LM |
| Mrp1 | ND | ||
| Mrp5 | ND | ||
| Choroid plexus | |||
| Peptide transporter | |||
| PepT2 | BBM | ||
| Organic anion transporter | |||
| Oatp1 | BBM | ||
| Oatp2 | BLM | ||
| Oatp3 | BBM | ||
| Primary active transporter | |||
| Oat3 | BBM | ||
| Mrp1 | BLM | ||
| Mdr1 | BBM | ||
SM, sinusoidal membrane; CM, canalicular membrane; BLM, basolateral membrane; BBM, brush border membrane; LM, luminal membrane, ALM, abluminal membrane.
↵a ND, not determined.