TABLE 7

Levels of radioactivity in female wild-type and Oct1−/− mice with a cannulated gallbladder at 60 min after i.v. injection of [14C]TEA (0.2 mg/kg) (Jonker et al., 2001)

14C concn (ng-eq g−1 or ml−1) ± SD (n = 4) Excretion (%)c Ratio (Oct1−/−/wt)
wta Oct1−/− wt Oct1−/−
Plasma 23.8 ± 4.9 17.1 ± 3.0* 0.72
Brain 1.6 ± 0.3 1.9 ± 0.4 1.22
Spleen 35 ± 5 42 ± 2* 1.21
Kidney 441 ± 152 236 ± 20* 0.53
Liver 1225 ± 26 (25.3±0.8b) 283 ± 44**(5.8±1.0**) 0.23
Bile 0.35 ± 0.09 0.14 ± 0.01* 0.41
Small intestine 1.31 ± 0.19 0.67 ± 0.09** 0.51
Cecum 0.12 ± 0.02 0.09 ± 0.04* 0.72
Colon 0.03 ± 0.01 0.04 ± 0.01 1.23
Urine 53.3 ± 16.8 80.0 ± 15.6* 1.50

  • *P < 0.05; ** P < 0.01.

  • ↵ a wt, wild type.

  • ↵ b Mean percentage of administered does ± SD (n = 4).

  • ↵ c Total TEA found in the contents of small intestine, cecum, and colon. Urine was collected from the bladder.