TABLE 2

Target genes of the xenosensors CXR, PXR, and CAR ^a

Class	Gene	Organism	Response Element	Receptor	Reference
Drug oxidation (phase I)	Cyp1a1	Mouse	?	CAR	Maglich et al., 2002
	CYP1a2	Mouse	?	CAR	Maglich et al., 2002
	CYP2a4	Mouse	?	CAR	Maglich et al., 2002
	CYP2B1/2	Rat	DR-4	CAR, PXR	Sueyoshi and Negishi, 2001
	CYP2B6	Human	DR-4	CAR, PXR	Sueyoshi and Negishi, 2001
	CYP2b10	Mouse	DR-4	CAR, PXR	Sueyoshi and Negishi, 2001
	CYP2C8	Human	DR-4	PXR	Ferguson et al., 2002b
	CYP2C9	Human	DR-4	CAR, PXR	Gerbal-Chaloin et al., 2002
	CYP2C19	Human	DR-4	CAR	Ferguson et al., 2002a
	CYP2C45	Chicken	DR-4	CXR	Baader et al., 2002
	CYP2H1	Chicken	DR-4	CXR	Handschin and Meyer, 2000
	CYP3A2	Rat	DR-3	PXR	Sueyoshi and Negishi, 2001
	CYP3A4	Human	ER-6, DR-3, DR-4	PXR, CAR	Sueyoshi and Negishi, 2001
	CYP3A7	Human	ER-6	PXR	Sueyoshi and Negishi, 2001
	CYP3a11	Mouse	?	PXR, CAR	Maglich et al., 2002
	CYP3A23	Rat	DR-4	PXR	Sueyoshi and Negishi, 2001
	CYP3A37	Chicken	DR-4	CXR	Podvinec et al., 2002
	Aldh1	Mouse	?	PXR, CAR	Maglich et al., 2002
	Est1	Mouse	?	CAR	Ueda et al., 2002a
	F-monoox.	Mouse	?	CAR	Ueda et al., 2002a
Drug conjugation (phase II)	GST	Mouse	?	CAR	Maglich et al., 2002
	Sultn	Mouse	?	CAR	Maglich et al., 2002
	Std	Mouse	IR-0	PXR	Sonoda et al., 2002
	UGT1A1	Human	DR-4	CAR	Sugatani et al., 2001
	Ugt1a1	Mouse	?	PXR	Maglich et al., 2002
Drug import/export	MDR1	Human	DR-4	PXR	Geick et al., 2001
	Mdr1a	Mouse	?	PXR, CAR	Maglich et al., 2002
	Mdr1b	Mouse	?	PXR	Maglich et al., 2002
	Mrp1	Mouse	?	CAR	Maglich et al., 2002
	Mrp2	Mouse	ER-8	PXR, CAR	Kast et al., 2002
	Mrp3	Mouse	?	PXR, CAR	Maglich et al., 2002
	Oatp2	Mouse	?	PXR	Maglich et al., 2002
	OATP2	Rat	DR-3	PXR	Guo et al., 2002
Essential accessory proteins	ALAS1	Chicken	DR-4	CXR	Fraser et al., 2002
	Alas1	Mouse	?	PXR, CAR	Maglich et al., 2002
	Methyltransferase	Mouse	?	CAR	Ueda et al., 2002a
	PAPS synthase	Mouse	?	CAR, PXR	Ueda et al., 2002a
	Por	Mouse	?	PXR, CAR	Maglich et al., 2002
Receptors	AhR	Mouse	?	CAR	Maglich et al., 2002
	CAR	Mouse	?	PXR	Maglich et al., 2002
	ear-2	Human	?	CAR	Sugatani et al., 2001
	PXR	Mouse	?	PXR	Maglich et al., 2002
Other enzymes and proteins	Aquaporin 1	Mouse	?	CAR	Ueda et al., 2002a
	cAMP-reg. PP	Mouse	?	CAR	Ueda et al., 2002a
	IGFBP1	Human	?	CAR	Sugatani et al., 2001
	HD	Mouse	DR-2	CAR	Kassam et al., 2000
	iNOS	Human	DR-4	PXR, CAR	Toell et al., 2002
	Semaphorin-3	Mouse	?	CAR	Ueda et al., 2002a
	SOD3	Human	?	CAR	Sugatani et al., 2001

↵ a List of target genes that are induced by any of the xenosensors. Genes included were identified as direct target genes with response elements or found to be reduced in PXR or CAR knockout animals. References are either reviews or primary papers describing the respective genes. See text for details or further references. Abbreviations: Aldh, aldehyde dehydrogenase; Est, esterase; GST, glutathione S-transferase; Sultn, sulfotransferase; Std, dehydroepiandrosterone sulfotransferase; UGT, UDP-glucuronosyl transferase; Mdr, intestinal P-glycoprotein; Mrp, multidrug-resistance protein; Oatp, organic anion transporting peptide; F-monoox, flavin containing mono-oxygenase; Por, cytochrome P450 oxidoreductase; iNOS, inducible nitric-oxide synthase; cAMP-reg. PP, cAMP-regulated phosphoprotein; SOD, superoxide dismutase; IGFBP, insulin-like growth factor-binding protein; HD, enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase