TABLE 3

Prodrugs activated by aldehyde oxidases

Prodrug Drug Pharmacology Reference
5-Ethynyl-2(1H)-pyrimidinone 5-Ethynyluracil Mechanism-based inhibitor of DPD Porter et al., 1994
IPdR IUdR Radiosensitizer Kinsella et al., 1994
5-FP 5-FU Thymidylate synthase inhibitor/incorporated into DNA and RNA Guo et al., 1995