Prodrugs activated by cytochrome P450 reductase
| Prodrug | Drug | Pharmacology | Reference |
|---|---|---|---|
| Menadione | Semiquinone radical | DNA alkylation/oxidative stress | Misaka and Nakanishi, 1965 |
| Mitomycin C | Quinone methide intermediate | DNA alkylation/ oxidative stress | Bachur et al., 1979 |
| Tirapazamine | Nitroxide radical | DNA alkylation/ oxidative stress | Walton et al., 1989 |
| EO9 | Unidentified semiquinone radical | DNA alkylation/ oxidative stress | Saunders et al., 2000a |