TABLE 3

Old age in humans and estimates of glomerular filtration rate

Date of Study Age Range No. Subjects Renal Clearance Reference
Substance Youngest or 20 years Oldest or >80 years Decrease in clearance in old age
1950 25-89 70 Vascular disease in older subjects Inulin 123 ml/min/1.73 m2 65 ml/min/1.73 m2 46% Davies and Shock, 1950
1976 18-92 249 Creatinine 114.9 ml/min 37.4 68% Cockcroft and Gault, 1976
1985 30-90 254 Baltimore Study, included hypertension Creatinine 156 ml/min 94 40% Lindeman et al., 1985
1989 19-93 30 Ambulatory volunteers Creatinine 117 ml/min 53 55% Friedman et al., 1989
1994 40-95 279 Healthy females Creatinine 94 ml/min/1.73 m2 66 30% Sokoll et al., 1994
1997 26 ± 3 vs 68 ± 7 53 Healthy nonhypertensive volunteers Inulin 121 ml/min/1.73 m2 103 15% Fliser et al., 1997a
1999 18-86 1629 Kuna Indians and Bostonians p-Aminohippurate, inulin Bostonians, 129 ml/min Kuna, 143 ml/min 107, 86 17%, 40% Hollenberg et al., 1999
2000 1-80 143 Outpatients EDTA 78 ml/min/1.73 m2 67 14% Peters et al., 2000
2001 25-78 43 Healthy volunteers Creatinine ∼145 ml/min/1.73 m2 ∼100 30% Adachi et al., 2001
2001 19-76 21 Potential kidney donors Inulin 127 ml/min/1.73 m2 76 ml/min/1.73 m2 40% Fuiano et al., 2001
2001 25-67 53 Healthy young, hypertensive old Inulin 119 ml/min/1.73 m2 104 ml/min/1.73 m2 13% Fliser and Ritz, 2001