TABLE 4

The effects of aging on the pharmacokinetics of lithium ( Sproule et al., 2000 )

No of Subjects	Age Range	Young		Old		References
No of Subjects	Age Range	V_d	CL	V_d	CL	References
		l/kg	l/h	l/kg	l/h
6	73-88			0.52	0.83	Chapron et al., 1982
9	67-80			0.64	0.94	Hardy et al., 1987
10 6	23-28	1.2	2.49	0.92	1.00	Lehmann and Merten, 1974
	52-65
Review		0.5-1.2	0.6-2.4			Sproule et al., 2000