TABLE 5

CYP2A6 allele frequency distribution in various populations a

Allele African-Americans Caucasians Chinese Japanese Koreans Native Canadians Sri Lankans Thais References
% % % % % % % %
CYP2A6*1B b 13.0 33.5 51.3 42.5 37.1 55.0 31.5 39.7 Ariyoshi et al., 2002a; Yoshida et al., 2002; Ujjin et al., 2002; Topcu et al., 2002; Schoedel et al., 2004
CYP2A6*1X2 0 0.7 0.4 0 0.2 0 Yoshida et al., 2002; Schoedel et al., 2004
CYP2A6*2 1.1 2.2 0 0 0 0 Kitagawa et al., 2001; Yoshida et al., 2002; Schoedel et al., 2004
CYP2A6*3 c 0 0 0 0 0 Oscarson et al., 1999a; Kitagawa et al., 2001; Paschke et al., 2001; Yoshida et al., 2002
CYP2A6*4 1.9 1.2 7.6 20.4 11.0 1.0 9.6 7.8 Ariyoshi et al., 2002a; Topcu et al., 2002; Yoshida et al., 2002; Ujjin et al., 2002; Wang et al., 2003b; Schoedel et al., 2004
CYP2A6*5 0 0.1 0.5 0 0.5 0.5 Yoshida et al., 2002; Schoedel et al., 2004
CYP2A6*6 0 0 0 0.2 0 0 Kitagawa et al., 2001; Yoshida et al., 2002; Schoedel et al., 2004
CYP2A6*7 0 0.3 3.1 6.5 3.6 0 Yoshida et al., 2002; Schoedel et al., 2004
CYP2A6*8 0 0.1 3.6 2.2 1.4 0 Yoshida et al., 2002; Schoedel et al., 2004
CYP2A6*9 7.1 7.1 15.7 21.3 22.3 15.5 Pitarque et al., 2001; Yoshida et al., 2003; Schoedel et al., 2004
CYP2A6*10 0 0 0.4 1.1 0.5 0 Yoshida et al., 2002; Schoedel et al., 2004
CYP2A6*11 0 0.6 0.7 Daigo et al., 2002; Nakajima et al., 2002a; Kiyotani et al., 2003
CYP2A6*12 0.4 2.0 0 0.8 0.5 Schoedel et al., 2004
CYP2A6*13 0 1.5 Kiyotani et al., 2002
CYP2A6*14 3.6 0 Kiyotani et al., 2002
CYP2A6*15 0 1.5 Kiyotani et al., 2002
CYP2A6*16 3.6 0 Kiyotani et al., 2002
CYP2A6*17 9.4 0 0 0 Fukami et al., 2004
• a As the data are gathered from several studies with differing methodologies, the reader is advised to interpret them with caution. If more than one study reports allele frequencies for a given allele in an ethnic group, the percentage shown is selected taking into account the technique used, the scope of the genotypes studied, and the number of subjects

• b Since only the domain swap in the 3′-untranslated region was investigated in these studies, more precise nomenclature (e.g. CYP2A6*1B1) cannot be used

• c CYP2A6*3 may be an artefact (Oscarson et al., 1998)