CYP2A6 allele frequency distribution in various populations a
| Allele | African-Americans | Caucasians | Chinese | Japanese | Koreans | Native Canadians | Sri Lankans | Thais | References |
|---|---|---|---|---|---|---|---|---|---|
| % | % | % | % | % | % | % | % | ||
| CYP2A6*1B b | 13.0 | 33.5 | 51.3 | 42.5 | 37.1 | 55.0 | 31.5 | 39.7 | Ariyoshi et al., 2002a; Yoshida et al., 2002; Ujjin et al., 2002; Topcu et al., 2002; Schoedel et al., 2004 |
| CYP2A6*1X2 | 0 | 0.7 | 0.4 | 0 | 0.2 | 0 | Yoshida et al., 2002; Schoedel et al., 2004 | ||
| CYP2A6*2 | 1.1 | 2.2 | 0 | 0 | 0 | 0 | Kitagawa et al., 2001; Yoshida et al., 2002; Schoedel et al., 2004 | ||
| CYP2A6*3 c | 0 | 0 | 0 | 0 | 0 | Oscarson et al., 1999a; Kitagawa et al., 2001; Paschke et al., 2001; Yoshida et al., 2002 | |||
| CYP2A6*4 | 1.9 | 1.2 | 7.6 | 20.4 | 11.0 | 1.0 | 9.6 | 7.8 | Ariyoshi et al., 2002a; Topcu et al., 2002; Yoshida et al., 2002; Ujjin et al., 2002; Wang et al., 2003b; Schoedel et al., 2004 |
| CYP2A6*5 | 0 | 0.1 | 0.5 | 0 | 0.5 | 0.5 | Yoshida et al., 2002; Schoedel et al., 2004 | ||
| CYP2A6*6 | 0 | 0 | 0 | 0.2 | 0 | 0 | Kitagawa et al., 2001; Yoshida et al., 2002; Schoedel et al., 2004 | ||
| CYP2A6*7 | 0 | 0.3 | 3.1 | 6.5 | 3.6 | 0 | Yoshida et al., 2002; Schoedel et al., 2004 | ||
| CYP2A6*8 | 0 | 0.1 | 3.6 | 2.2 | 1.4 | 0 | Yoshida et al., 2002; Schoedel et al., 2004 | ||
| CYP2A6*9 | 7.1 | 7.1 | 15.7 | 21.3 | 22.3 | 15.5 | Pitarque et al., 2001; Yoshida et al., 2003; Schoedel et al., 2004 | ||
| CYP2A6*10 | 0 | 0 | 0.4 | 1.1 | 0.5 | 0 | Yoshida et al., 2002; Schoedel et al., 2004 | ||
| CYP2A6*11 | 0 | 0.6 | 0.7 | Daigo et al., 2002; Nakajima et al., 2002a; Kiyotani et al., 2003 | |||||
| CYP2A6*12 | 0.4 | 2.0 | 0 | 0.8 | 0.5 | Schoedel et al., 2004 | |||
| CYP2A6*13 | 0 | 1.5 | Kiyotani et al., 2002 | ||||||
| CYP2A6*14 | 3.6 | 0 | Kiyotani et al., 2002 | ||||||
| CYP2A6*15 | 0 | 1.5 | Kiyotani et al., 2002 | ||||||
| CYP2A6*16 | 3.6 | 0 | Kiyotani et al., 2002 | ||||||
| CYP2A6*17 | 9.4 | 0 | 0 | 0 | Fukami et al., 2004 |
↵ a As the data are gathered from several studies with differing methodologies, the reader is advised to interpret them with caution. If more than one study reports allele frequencies for a given allele in an ethnic group, the percentage shown is selected taking into account the technique used, the scope of the genotypes studied, and the number of subjects
↵ b Since only the domain swap in the 3′-untranslated region was investigated in these studies, more precise nomenclature (e.g. CYP2A6*1B1) cannot be used
↵ c CYP2A6*3 may be an artefact (Oscarson et al., 1998)