TABLE 2

Class 2 G protein-coupled receptors Family represents the classification of orphan receptors adapted from Vassilatis et al. (2003). The IUPHAR Receptor Code is described in Humphrey and Barnard (1998). A representative, but not necessarily complete list of putative endogenous ligands is given. Provisional nomenclature is given in square brackets. Gene symbol approved by the HUGO Gene Nomenclature Committee (http://www.gene.ucl.ac.uk/nomenclature/). Gene IDs from Entrez Gene (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene). For definition of LNBTM7 receptors seeStacey et al., 2000.

Family IUPHAR Receptor Code Ligand Official IUPHAR Nomenclature Human Gene Symbol Human Gene ID Mouse Gene ID Rat Gene ID
Calcitonin receptor family 2.2.CALC:1:CT: Calcitonin CT CALCR 799 12311 116506
Calcitonin receptor family 2.2.CALC:2:AMY1: Amylin, CGRP AMY1a CALCR 799 12311 116506
RAMP1 10267 51801 58965
Calcitonin receptor family 2.2.CALC:3:AMY2: Amylin AMY2a CALCR 799 12311 116506
RAMP2 10266 54409 58966
Calcitonin receptor family 2.2.CALC:4:AMY3: Amylin, CGRP AMY3a CALCR 799 12311 116506
RAMP3 10268 56089 56820
Calcitonin receptor family CALCRL 10203 54598 25029
Calcitonin receptor family 2.2.CALCL:1: CGRP1: CGRP, adrenomedullin CGRP1a CALCRL 10203 54598 25029
RAMP1 10267 51801 58965
Calcitonin receptor family 2.2.CALCL:1:AM1: Adrenomedullin, CGRP AM1a CALCRL 10203 54598 25029
RAMP2 10266 54409 58966
Calcitonin receptor family 2.2.CALCL:1:AM2: Adrenomedullin, CGRP AM2a CALCRL 10203 54598 25029
RAMP3 10268 56089 56820
CRF receptor family 2.2:CRF:1:CRF1: Corticotropin releasing factor, urocortins CRF1 CRHR1 1394 12921 58959
CRF receptor family 2.2:CRF:2:CRF2: Urocortins CRF2 CRHR2 1395 12922 64680
Glucagon receptor family 2.2:GHRH:1:GHRH: Growth hormone-releasing hormone GHRH GHRHR 2692 14602 25321
Glucagon receptor family 2.2:GIP:1:GIP: Gastric inhibitory polypeptide GIP GIPR 2696 107830 25024
Glucagon receptor family 2.2:GLP1:1:GLP1: Glucagon-like peptide 1 GLP-1 GLP1R 2740 14652 25051
Glucagon receptor family 2.2:GLP2:1:GLP2: Glucagon-like peptide 2 GLP-2 GLP2R 9340 93896 60432
Glucagon receptor family 2.2:GCG:1:GCG: Glucagon Glucagon GCGR 2642 14527 24953
Glucagon receptor family 2.2:SEC:1:SEC: Secretin Secretin SCTR 6344 319229 81779
PTH receptor family 2.2:PTH:2:PTH2: TIP-39 [PTH2] PTHR2 5746 213527 81753
PTH receptor family 2.2:PTH:1:PTH1: Parathyroid hormone [PTH1] PTHR1 5745 19228 56813
VIP/PACAP 2.2:VPAC:1:VPAC1: VIP, PACAP VPAC1 VIPR1 7433 22354 24875
VIP/PACAP 2.2:VPAC:2:PAC1: PACAP PAC1 ADCYAP1R1 117 11517 24167
VIP/PACAP 2.2:VPAC:3:VPAC2: VIP, PACAP VPAC2 VIPR2 7434 22355 29555
LNB7TM GPR64 10149 237175
LNB7TM GPR56 9289 14766
LNB7TM GPR115 221393
LNB7TM GPR114 221188
LNB7TM:Brain specific angiogenesis inhibitor BAI1 575 107831
LNB7TM:Brain specific angiogenesis inhibitor BAI2 576 230775
LNB7TM:Brain specific angiogenesis inhibitor BAI3 577 210933
LNB7TM:Proto-cadherin CELSR1 9620 12614 300128
LNB7TM:Proto-cadherin CELSR2 1952 53883 83465
LNB7TM:Proto-cadherin CELSR3 1951 107934
LNB7TM:EGF, mucin-like receptor EMR1 2015 13733
LNB7TM:EGF, mucin-like receptor EMR2 30817 Absent Absent
LNB7TM GPR97 222487 54672
LNB7TM GPR110 266977
LNB7TM GPR111 222611
LNB7TM GPR112 139378
LNB7TM GPR113 165082
LNB7TM GPR116 221395
LNB7TM MASS1 84059 110789
LNB7TM ELTD1 64123 64124
LNB7TM GPR123 84435
LNB7TM GPR124 25960 78560
LNB7TM GPR125 166647
LNB7TM GPR126 57211
LNB7TM GPR128 84873
LNB7TM GPR144 347088
LNB7TM:EGF, mucin-like receptor EMR3 84658 Absent Absent
LNB7TM:EGF, mucin-like receptor EMR4b 326342 52614
LNB7TM CD97 976 26364
LNB7TM:Latrophilin substrate LPHN2 23266 99633
LNB7TM:Latrophilin substrate LPHN3 23284 319387
LNB7TM:Latrophilin substrate LPHN1 22859 330814
Unclassified GPR157 80045
  • CGRP, calcitonin gene-related peptide; PACAP, pituitary adenylate cyclase activating polypeptide; TIP-39, tuberoinfundibular peptide of 39 residues; VIP, vasoactive intestinal peptide.

  • a Functional receptor is a dimer of 7TM and RAMP

  • b Probable pseudogene