TABLE 4

Frizzled family receptors A representative, but not necessarily complete list of putative endogenous ligands is given. Provisional nomenclature is given in square brackets. Gene symbol approved by the HUGO Gene Nomenclature Committee (http://www.gene.ucl.ac.uk/nomenclature/). Gene IDs from Entrez Gene (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene).

Family Ligand Official IUPHAR Nomenclature Human Gene Symbol Human Gene ID Mouse Gene ID Rat Gene ID
Frizzled Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2 [FZD1] FZD1 8321 14362 58868
Frizzled Wnt [FZD2] FZD2 2535 57265 64512
Frizzled Wnt [FZD3] FZD3 7976 14365 266715
Frizzled Wnt, Wnt5a, and NDP [FZD4] FZD4 8322 14366 64558
Frizzled Wnt and Wnt5a [FZD5] FZD5 7855 14367 317674
Frizzled Wnt [FZD6] FZD6 8323 14368 282581
Frizzled Wnt and Wnt5a [FZD7] FZD7 8324 14369
Frizzled Wnt and Wnt1 [FZD8] FZD8 8325 14370
Frizzled Wnt and Wnt2 [FZD9] FZD9 8326 14371 266608
Frizzled Wnt [FZD10] FZD10 11211 93897
Smoothened Constitutive [SMO] SMO 6608 20596 25273