HCN3 channels

Channel name HCN31,2
Description Hyperpolarization-activated, cyclic nucleotide-gated cation channel
Other names HAC3, BCNG4
Molecular information Human: 774aa, NM_020897, NP_065948, chr. 1q22
Rat: 780aa, NM_053685, NP_446137, chr. 2q34
Mouse: 779aa, NM_008227, NP_032253, chr. 3 F2
Associated subunits Not established
Functional assays Voltage-clamp
Current Ih, If, or Iq
Conductance Not established
Ion selectivity Not established
Activation V0.5 = -95 mV; ta = 260 ms at -140 mV (values are strongly influenced by experimental parameters such as temperature, pH, and pulse protocol)
Inactivation No inactivation
Activators None
Gating modifiers None
Blockers None
Radioligands None
Channel distribution Brain, retina, heart
Physiological functions Not established
Mutations and pathophysiology Not established
Pharmacological significance Not established
  • aa, amino acids; chr., chromosome.

  • 1. Ludwig A, Zong X, Jeglitsch M, Hofmann F, and Biel M (1998) A family of hyperpolarization-activated mammalian cation channels. Nature (Lond) 393:587-591

  • 2. Monteggia LM, Eisch AJ, Tang MD, Kaczmarek LK, and Nestler EJ (2000) Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Brain Res Mol Brain Res 81:129-139