HCN3 channels
| Channel name | HCN31,2 |
| Description | Hyperpolarization-activated, cyclic nucleotide-gated cation channel |
| Other names | HAC3, BCNG4 |
| Molecular information | Human: 774aa, NM_020897, NP_065948, chr. 1q22 |
| Rat: 780aa, NM_053685, NP_446137, chr. 2q34 | |
| Mouse: 779aa, NM_008227, NP_032253, chr. 3 F2 | |
| Associated subunits | Not established |
| Functional assays | Voltage-clamp |
| Current | Ih, If, or Iq |
| Conductance | Not established |
| Ion selectivity | Not established |
| Activation | V0.5 = -95 mV; ta = 260 ms at -140 mV (values are strongly influenced by experimental parameters such as temperature, pH, and pulse protocol) |
| Inactivation | No inactivation |
| Activators | None |
| Gating modifiers | None |
| Blockers | None |
| Radioligands | None |
| Channel distribution | Brain, retina, heart |
| Physiological functions | Not established |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
aa, amino acids; chr., chromosome.
↵1. Ludwig A, Zong X, Jeglitsch M, Hofmann F, and Biel M (1998) A family of hyperpolarization-activated mammalian cation channels. Nature (Lond) 393:587-591
↵2. Monteggia LM, Eisch AJ, Tang MD, Kaczmarek LK, and Nestler EJ (2000) Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Brain Res Mol Brain Res 81:129-139