KV3.3 channels

Channel name KV3.31,2,3,4
Description Voltage-gated A-type potassium channel2
Other names hKv3.3, mKv3.3,1 RKShIIID,3 Kv3.3b4
Molecular information Human: 757aa, NM_004977, chr. 19q13.3-4,1,2,3 KCNC3, GeneID: 3748, PMID: 17403291
Mouse: 679aa, NM_008422, chr. 7
Rat: 770aa, NM_053997, chr. 1q22
Associated subunits None
Functional assays Electrophysiology
Current A-type
Conductance Not established
Ion selectivity K+
Activation Va = 7 mV; ka = 6 mV2
Inactivation τh ∼ 200 ms (40 mV)2
Activators None
Gating inhibitors None
Blockers Tetraethyammonium (0.14 mM),2 4-aminopyridine (1.2 mM)2; blocked by hypoxia5
Radioligands None
Channel distribution Brain, Purkinje cells, central nervous system motoneurons; auditory brainstem12; electrosensory, cerebellar neurons, central auditory nuclei6,7,8; mesenteric artery9; lens and corneal epithelium10
Physiological functions Not established
Mutations and pathophysiology See “Comments”
Pharmacological significance Not established
Comments Alcohol hypersensitivity, ataxia, increased locomotion and myoclonus occur in mice lacking KV3.3 and KV3.111; mammalian Shaw-related family
  • aa, amino acids; chr., chromosome.

  • 1. Ghanshani S, Pak M, McPherson JD, Strong M, Dethlefs B, Wasmuth JJ, Salkoff L, Gutman GA, and Chandy KG (1992) Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics 12:190-196

  • 2. Vega-Saenzde Miera E, Moreno H, Fruhling D, Kentros C, and Rudy B (1992) Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel. Proc R Soc Lond B Biol Sci 248:9-18

  • 3. Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, and Rudy B (1993) Localization of Shaw-related K+ channel genes on mouse and human chromosomes. Mamm Genome 4:711-715

  • 4. Goldman-Wohl DS, Chan E, Baird D, and Heintz N (1994) Kv3.3b: a novel Shaw type potassium channel expressed in terminally differentiated cerebellar Purkinje cells and deep cerebellar nuclei. J Neurosci 14:511-522

  • 5. Patel AJ and Honore E (2001) Molecular physiology of oxygen-sensitive potassium channels. Eur Respir J 18:221-227

  • 6. Rashid AJ, Dunn RJ, and Turner RW (2001) A prominent soma-dendritic distribution of Kv3.3 K+ channels in electrosensory and cerebellar neurons. J Comp Neurol 441:234-247

  • 7. Grigg JJ, Brew HM, and Tempel BL (2000) Differential expression of voltage-gated potassium channel genes in auditory nuclei of the mouse brainstem. Hear Res 140:77-90

  • 8. Li W, Kaczmarek LK, and Perney TM (2001) Localization of two high-threshold potassium channel subunits in the rat central auditory system. J Comp Neurol 437:196-218

  • 9. Xu C, Lu Y, Tang G, and Wang R (1999) Expression of voltage-dependent K+ channel genes in mesenteric artery smooth muscle cells. Am J Physiol 277:G1055-G1063

  • 10. Rae JL and Shepard AR (2000) Kv3.3 potassium channels in lens epithelium and corneal endothelium. Exp Eye Res 70:339-348

  • 11. Espinosa F, McMahon A, Chan E, Wang S, Ho CS, Heintz N, and Joho RH (2001) Alcohol hyper-sensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3. J Neurosci 21:6657-6665

  • 12. Weiser M, Bueno E, Sekirnjak C, Martone ME, Baker H, Hillman D, Chen S, Thornhill W, Ellisman M, and Rudy B (1995) The potassium channel subunit KV3.1b is localized to somatic and axonal membranes of specific populations of CNS neurons. J Neurosci 15:4298-4314