KV3.4 channels
| Channel name | KV3.4 |
| Description | Voltage-gated potassium channel, A-type, fast-inactivating |
| Other names | Raw3,1 HKShIIIC,2 mKv3.43 |
| Molecular information | Human: 635 aa, NM_004978 (transcript variant 1), chr. 1p211,2, KCNC4, GeneID: 3749, PMID: 19205362 |
| Mouse: 628 aa, NM_145922, chr. 3 | |
| Rat: | |
| Associated subunits | MiRP2 forms potassium channels in skeletal muscle with KV3.44 |
| Functional assays | Electrophysiology |
| Current | A-type |
| Conductance | 14pS1,5 |
| Ion selectivity | K+ |
| Activation | Va = 3.4 mV5, +14 mV1; ka = 8.4 mV5 |
| Inactivation | N-type inactivation, Vh = 53 mV; kh = 7.4 mV; τh = 15.9 ms (50 mV)1,2,5 |
| Activators | None |
| Gating inhibitors | None |
| Blockers | BDS-I (47 nM),6 tetraethyammonium (0.3 mM)1,5; the specificity of BDS-I for KV3.4 has been questioned12 |
| Radioligands | None |
| Channel distribution | Parathyroid, prostate, brain7 (brainstem, hippocampal granule cells),8 skeletal muscle,4,8,9 pancreatic acinar cells10,11 |
| Physiological functions | Together with MirP2 forms low-voltage-ctivating potassium channels that regulate skeletal muscle resting potential4 |
| Mutations and pathophysiology | Mutations of MiRP2, which associates with KV3.4 in skeletal muscle, are associated with periodic paralysis4 |
| Pharmacological significance | Not established |
| Comments | Mammalian Shaw-related family |
aa, amino acids; chr., chromosome.
↵1. Schroter KH, Ruppersberg J, Wunder F, Rettig J, Stocker M, and Pongs O (1991) Cloning and functional expression of a TEA-sensitive A-type potassium channel from rat brain. FEBS Lett 278:211-216
↵2. Rudy B, Sen K, Vega-Saenz de Miera E, Lau D, Ried T, and Ward DC (1991) Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21. J Neurosci Res 29:401-412
↵3. Ghanshani S, Pak M, McPherson JD, Strong M, Dethlefs B, Wasmuth JJ, Salkoff L, Gutman GA, and Chandy KG (1992) Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics 12:190-196
↵4. Abbott GW, Butler MH, Bendahhou S, Dalakas MC, Ptacek LJ, and Goldstein SA (2001) MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell 104:217-231
↵5. Rettig J, Wunder F, Stocker M, Lichtinghagen R, Mastiaux F, Beckh S, Kues W, Pedarzani P, Schroter KH, Ruppersberg JP, et al. (1992) Characterization of a Shaw-related potassium channel family in rat brain. EMBO J 11:2473-2486
↵6. Diochot S, Schweitz H, Beress L, and Lazdunski M (1998) Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. J Biol Chem 273:6744-6749
↵7. Riazanski V, Becker A, Chen J, Sochivko D, Lie A, Wiestler OD, Elger CE, and Beck H (2001) Functional and molecular analysis of transient voltage-dependent K+ currents in rat hippocampal granule cells. J Physiol 537:391-406
↵8. Weiser M, Vega-Saenz de Miera E, Kentros C, Moreno H, Franzen L, Hillman D, Baker H, and Rudy B (1994) Differential expression of Shaw-related K+ channels in the rat central nervous system. J Neurosci 14:949-972
↵9. Vullhorst D, Klocke R, Bartsch JW, and Jockusch H (1998) Expression of the potassium channel KV3.4 in mouse skeletal muscle parallels fiber type maturation and depends on excitation pattern. FEBS Lett 421:259-262
↵10. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B, et al. (1998) Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J Biol Chem 273:5851-5857
↵11. Gopel SO, Kanno T, Barg S, and Rorsman P (2000) Patch-clamp characterisation of somatostatin-secreting-cells in intact mouse pancreatic islets. J Physiol 528:497-507
↵12. Yeung SYM, Thompson D, Wang Z, Fedida D, and Robertson B (2005) Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies. J Neurosci 25:8735-8745