KV5.1 channels
| Channel name | KV5.11,2,3,4 |
| Description | Modifier of the KV2 family of channels |
| Other names | KH1, IK8 |
| Molecular information | Human: 494aa, NM_002236, chr. 2p25,5 KCNF1, GeneID: 3754, PMID: 94347675 |
| Mouse: 493aa, NM_201531, chr. 12 | |
| Rat: 505aa, XM_216678 (predicted), chr. 6 | |
| Associated subunits | Associates with KV2.1 and KV2.2 |
| Functional assays | Voltage-clamp |
| Current | None |
| Conductance | Not functional on its own |
| Ion selectivity | Not functional on its own |
| Activation | Not functional on its own |
| Inactivation | Not functional on its own |
| Activators | None |
| Gating inhibitors | None |
| Blockers | None |
| Radioligands | None |
| Channel distribution | Brain, heart, skeletal muscle, liver, kidney pancreas,1,2,6 cardiac myocytes7 |
| Physiological functions | Modifies the gating properties of KV2.1 and KV2.2 channels |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | KV5.1 has no function on its own, but it has important modulatory actions on KV2 channels |
aa, amino acids; chr., chromosome.
↵1. Drewe JA, Verma S, Frech G, and Joho RH (1992) Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies. J Neurosci 12:538-548
↵2. Verma-Kurvari S, Border B, and Joho RH (1997) Regional and cellular expression patterns of four K+ channel mRNAs in the adult rat brain. Brain Res Mol Brain Res 46:54-62
↵3. Salinas M, Duprat F, Heuteaux C, Hugnot JP, and Lazdunski M (1997) New modulatory α subunits for mammalian Shab K+ channels. J Biol Chem 272:24371-24379
↵4. Kramer JW, Post MA, Brown AM, and Kirsch GE (1998) Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 α-subunits. Am J Physiol 274:C1501-C1510
↵5. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, and Li Y (1997) Isolation, characterization, and mapping of two human potassium channels. Biochem Biophys Res Commun 241:675-681
↵6. UniGeneCluster Hs0.23735; OMIM no. 603787
↵7. Brahmajothi MV, Morales MJ, Liu S, Rasmusson RL, Campbell DL, and Strauss HC (1996) In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes. Circ Res 78:1083-1089