KV5.1 channels

Channel name KV5.11,2,3,4
Description Modifier of the KV2 family of channels
Other names KH1, IK8
Molecular information Human: 494aa, NM_002236, chr. 2p25,5 KCNF1, GeneID: 3754, PMID: 94347675
Mouse: 493aa, NM_201531, chr. 12
Rat: 505aa, XM_216678 (predicted), chr. 6
Associated subunits Associates with KV2.1 and KV2.2
Functional assays Voltage-clamp
Current None
Conductance Not functional on its own
Ion selectivity Not functional on its own
Activation Not functional on its own
Inactivation Not functional on its own
Activators None
Gating inhibitors None
Blockers None
Radioligands None
Channel distribution Brain, heart, skeletal muscle, liver, kidney pancreas,1,2,6 cardiac myocytes7
Physiological functions Modifies the gating properties of KV2.1 and KV2.2 channels
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments KV5.1 has no function on its own, but it has important modulatory actions on KV2 channels
  • aa, amino acids; chr., chromosome.

  • 1. Drewe JA, Verma S, Frech G, and Joho RH (1992) Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies. J Neurosci 12:538-548

  • 2. Verma-Kurvari S, Border B, and Joho RH (1997) Regional and cellular expression patterns of four K+ channel mRNAs in the adult rat brain. Brain Res Mol Brain Res 46:54-62

  • 3. Salinas M, Duprat F, Heuteaux C, Hugnot JP, and Lazdunski M (1997) New modulatory α subunits for mammalian Shab K+ channels. J Biol Chem 272:24371-24379

  • 4. Kramer JW, Post MA, Brown AM, and Kirsch GE (1998) Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 α-subunits. Am J Physiol 274:C1501-C1510

  • 5. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, and Li Y (1997) Isolation, characterization, and mapping of two human potassium channels. Biochem Biophys Res Commun 241:675-681

  • 6. UniGeneCluster Hs0.23735; OMIM no. 603787

  • 7. Brahmajothi MV, Morales MJ, Liu S, Rasmusson RL, Campbell DL, and Strauss HC (1996) In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes. Circ Res 78:1083-1089