KV6.1 channels
| Channel name | KV6.11,2,3,4,5,6 |
| Description | Modifier/silencer of KV2 family channels |
| Other names | KH2, K13 |
| Molecular information | Human: 513aa, NM_002237, chr. 20q13,6,7 KCNG1, GeneID: 3755, PMID: 94347676 |
| Mouse: 534aa, XM_141545 (predicted), chr. 2 | |
| Rat: 514aa, XM_215951 (predicted), chr. 3 | |
| Associated subunits | Associates with KV2 family channels |
| Functional assays | Electrophysiology |
| Current | None |
| Conductance | Not functional on its own |
| Ion selectivity | Not functional on its own |
| Activation | Not functional on its own |
| Inactivation | Not functional on its own |
| Activators | None |
| Gating inhibitors | None |
| Blockers | None |
| Radioligands | None |
| Channel distribution | Skeletal muscle, brain, uterus, ovary, kidney, pancreas, placenta, bone, germ cell, prostate, skin, testis,6,7 cardiac myocytes (sinoatrial node)8 |
| Physiological functions | KV6.1 subunits when expressed alone are unable to elicit any current— however, KV6.1 can suppress KV2.1 current (less effectively than KV5.1), and to a lesser extent it can suppress KV2.2; the KV2.1 currents are strongly modified by KV6.1, which increases the time constant of activation and slows down inactivation |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | KV6.1 has no function on its own, but it has important modulatory actions on KV2 channels |
aa, amino acids; chr., chromosome.
↵1. Drewe JA, Verma S, Frech G, and Joho RH (1992) Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies. J Neurosci 12:538-548
↵2. Post MA, Kirsch GE, and Brown AM (1996) Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current. FEBS Lett 399:177-182
↵3. Verma-Kurvari S, Border B, and Joho RH (1997) Regional and cellular expression patterns of four K+ channel mRNAs in the adult rat brain. Brain Res Mol Brain Res 46:54-62
↵4. Salinas M, Duprat F, Heurteaux C, Hugnot JP, and Lazdunsk, M (1997) New modulatory α subunits for mammalian Shab K+ channels. J Biol Chem 272:24371-24379
↵5. Kramer JW, Post MA, Brown AM, and Kirsch GE (1998) Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 α-subunits. Am J Physiol 274:C1501-C1510
↵6. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, and Li Y (1997) Isolation, characterization, and mapping of two human potassium channels. Biochem Biophys Res Commun 241:675-681
↵7. UniGene Cluster Hs0.118695; OMIM no. *603788
↵8. Brahmajothi MV, Morales MJ, Liu S, Rasmusson RL, Campbell DL, and Strauss HC (1996) In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes. Circ Res 78:1083-1089