KV6.1 channels

Channel name KV6.11,2,3,4,5,6
Description Modifier/silencer of KV2 family channels
Other names KH2, K13
Molecular information Human: 513aa, NM_002237, chr. 20q13,6,7 KCNG1, GeneID: 3755, PMID: 94347676
Mouse: 534aa, XM_141545 (predicted), chr. 2
Rat: 514aa, XM_215951 (predicted), chr. 3
Associated subunits Associates with KV2 family channels
Functional assays Electrophysiology
Current None
Conductance Not functional on its own
Ion selectivity Not functional on its own
Activation Not functional on its own
Inactivation Not functional on its own
Activators None
Gating inhibitors None
Blockers None
Radioligands None
Channel distribution Skeletal muscle, brain, uterus, ovary, kidney, pancreas, placenta, bone, germ cell, prostate, skin, testis,6,7 cardiac myocytes (sinoatrial node)8
Physiological functions KV6.1 subunits when expressed alone are unable to elicit any current— however, KV6.1 can suppress KV2.1 current (less effectively than KV5.1), and to a lesser extent it can suppress KV2.2; the KV2.1 currents are strongly modified by KV6.1, which increases the time constant of activation and slows down inactivation
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments KV6.1 has no function on its own, but it has important modulatory actions on KV2 channels
  • aa, amino acids; chr., chromosome.

  • 1. Drewe JA, Verma S, Frech G, and Joho RH (1992) Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies. J Neurosci 12:538-548

  • 2. Post MA, Kirsch GE, and Brown AM (1996) Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current. FEBS Lett 399:177-182

  • 3. Verma-Kurvari S, Border B, and Joho RH (1997) Regional and cellular expression patterns of four K+ channel mRNAs in the adult rat brain. Brain Res Mol Brain Res 46:54-62

  • 4. Salinas M, Duprat F, Heurteaux C, Hugnot JP, and Lazdunsk, M (1997) New modulatory α subunits for mammalian Shab K+ channels. J Biol Chem 272:24371-24379

  • 5. Kramer JW, Post MA, Brown AM, and Kirsch GE (1998) Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 α-subunits. Am J Physiol 274:C1501-C1510

  • 6. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, and Li Y (1997) Isolation, characterization, and mapping of two human potassium channels. Biochem Biophys Res Commun 241:675-681

  • 7. UniGene Cluster Hs0.118695; OMIM no. *603788

  • 8. Brahmajothi MV, Morales MJ, Liu S, Rasmusson RL, Campbell DL, and Strauss HC (1996) In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes. Circ Res 78:1083-1089