TABLE 21

KV6.2 channels

Channel name Kv6.21
Description Modifier/silencer
Other names None
Molecular information Human: 466aa, NM_012283, chr. 18q22—18q23,1 KCNG2, GeneID: 26251, PMID: 105512661
Mouse: AC145610 (genomic), chr. 18
Rat: 436aa, XM_225718 (predicted), chr. 18
Associated subunits Coassembles with Kv2 family channels via the N termini1
Functional assays Electrophysiology
Current None
Conductance Not functional on its own
Ion Selectivity Not functional on its own
Activation Not functional on its own
Inactivation Not functional on its own
Activators None
Gating inhibitors None
Blockers None
Radioligands None
Channel distribution Myocardium, fetal brain, germinal center B cells1,2
Physiological functions Modifier/silencer, coassembles with Kv2.1, producing K+ channels with unique properties
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments Kv6.2 has no function on its own, but it has important modulatory actions on Kv2 channels
  • aa, amino acids; chr., chromosome.

  • 1. Zhu XR, Netzer R, Bohlke K, Liu Q, and Pongs O (1999). Structural and functional characterization of Kv6.2: a new γ-subunit of voltage-gated potassium channel. Receptors Channels 6:337-350

  • 2. UniGene Cluster Hs0.247905; OMIM no. 605696