Channel name | Kv6.31 |
Description | Modifier/silencer |
Other names | Kv10.1 |
Molecular information | Human: 436aa, NM_133329, chr. 2p21, KCNG3, GeneID: 170850, PMID: 118520861 |
Mouse: 433aa, NM_153512, chr. 17 | |
Rat: 345aa, NM_133426, chr. 6q12 | |
Associated subunits | Coassembles with Kv2.11 |
Functional assays | Electrophysiology |
Current | None |
Conductance | Not functional on its own |
Ion selectivity | Not functional on its own |
Activation | Not functional on its own |
Inactivation | Not functional on its own |
Activators | None |
Gating inhibitors | None |
Blockers | None |
Radioligands | None |
Channel distribution | Whole brain (hippocampus, caudate nucleus, frontal lobe, hypothalamus, substantia nigra), spinal cord, pituitary, testis, small intestine, thymus, adrenal gland1 |
Physiological functions | Modifier/silencer, coassembles with Kv2.1 |
Mutations and pathophysiology | Not established |
Pharmacological significance | Not established |
Comments | Kv6.3 has no function on its own, but it has important modulatory actions on Kv2 channels |
aa, amino acids; chr., chromosome.
↵1. Sano Y, Mochizuki S, Miyake A, Kitada C, Inamura K, Yokoi H, Nozawa K, Matsushime H, and Furuichi K (2002) Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K+ channel Kv2.1. FEBS Lett 512:230-234