KV6.3 channels

Channel name Kv6.31
Description Modifier/silencer
Other names Kv10.1
Molecular information Human: 436aa, NM_133329, chr. 2p21, KCNG3, GeneID: 170850, PMID: 118520861
Mouse: 433aa, NM_153512, chr. 17
Rat: 345aa, NM_133426, chr. 6q12
Associated subunits Coassembles with Kv2.11
Functional assays Electrophysiology
Current None
Conductance Not functional on its own
Ion selectivity Not functional on its own
Activation Not functional on its own
Inactivation Not functional on its own
Activators None
Gating inhibitors None
Blockers None
Radioligands None
Channel distribution Whole brain (hippocampus, caudate nucleus, frontal lobe, hypothalamus, substantia nigra), spinal cord, pituitary, testis, small intestine, thymus, adrenal gland1
Physiological functions Modifier/silencer, coassembles with Kv2.1
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments Kv6.3 has no function on its own, but it has important modulatory actions on Kv2 channels
  • aa, amino acids; chr., chromosome.

  • 1. Sano Y, Mochizuki S, Miyake A, Kitada C, Inamura K, Yokoi H, Nozawa K, Matsushime H, and Furuichi K (2002) Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K+ channel Kv2.1. FEBS Lett 512:230-234