KV6.4 channels

Channel name KV6.41
Description Modifier/silencer
Other names None
Molecular information Human: 519aa, NM_172347 (transcript variant 1), chr. 16q24.1, KCNG4, GeneID: 93107, PMID: 120607451
Mouse: 506aa, NM_025734, chr. 8,
Rat: 506aa, XM_226524 (predicted), chr. 19
Associated subunits Coassembles with KV2.11
Functional assays Electrophysiology
Current Not functional on its own
Conductance Not functional on its own
Ion selectivity Not functional on its own
Activation Not functional on its own
Inactivation Not functional on its own
Activators None
Gating inhibitors None
Blockers None
Radioligands None
Channel distribution Brain, liver, small intestine, colon1
Physiological functions Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium currents; modulates the activity of KV2.1 channels by causing marked changes in activation threshold and kinetics, C-type inactivation, and deactivation1
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments KV6.4 has no function on its own, but it has important modulatory actions on KV2 channels
  • aa, amino acids; chr., chromosome.

  • 1. Ottschytsch N, Raes A, Van Hoorick D, and Snyders DJ (2002) Obligatory heterotetramerization of three previously uncharacterized Kv channel-subunits identified in the human genome. Proc Natl Acad Sci USA 99:7986-7991