KV6.4 channels
| Channel name | KV6.41 |
| Description | Modifier/silencer |
| Other names | None |
| Molecular information | Human: 519aa, NM_172347 (transcript variant 1), chr. 16q24.1, KCNG4, GeneID: 93107, PMID: 120607451 |
| Mouse: 506aa, NM_025734, chr. 8, | |
| Rat: 506aa, XM_226524 (predicted), chr. 19 | |
| Associated subunits | Coassembles with KV2.11 |
| Functional assays | Electrophysiology |
| Current | Not functional on its own |
| Conductance | Not functional on its own |
| Ion selectivity | Not functional on its own |
| Activation | Not functional on its own |
| Inactivation | Not functional on its own |
| Activators | None |
| Gating inhibitors | None |
| Blockers | None |
| Radioligands | None |
| Channel distribution | Brain, liver, small intestine, colon1 |
| Physiological functions | Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium currents; modulates the activity of KV2.1 channels by causing marked changes in activation threshold and kinetics, C-type inactivation, and deactivation1 |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | KV6.4 has no function on its own, but it has important modulatory actions on KV2 channels |
aa, amino acids; chr., chromosome.
↵1. Ottschytsch N, Raes A, Van Hoorick D, and Snyders DJ (2002) Obligatory heterotetramerization of three previously uncharacterized Kv channel-subunits identified in the human genome. Proc Natl Acad Sci USA 99:7986-7991