KV7.5 channels

Channel name KV7.5
Description Voltage-gated potassium channel, delayed rectifier
Other names None
Molecular information Human: 932aa, NM_019842, chr. 6q14, KCNQ,1,5 GeneID: 56479, PMID: 107874161
Mouse: 933aa, NM_023872, chr. 1
Rat: 953aa, XM_237012 (predicted), chr. 9
Associated subunits KCNQ3
Functional assays Voltage-clamp
Current M current1
Conductance Not established
Ion selectivity K+
Activation Va = 30 mV
Inactivation Not established
Activator Retigabine (KCNQ5/KCNQ3: 1.4 μM),2 BMS204352 (2.4 μM)3
Gating inhibitors None
Blockers Tetraethyammonium (>30 mM),1 linopiridine (16 μM),1 linopiridine KCNQ5/KCNQ3 (7.7 μM),2 XE9913
Radioligands None
Channel distribution Brain, sympathetic ganglia (splice variant I),4 skeletal muscle (splice variant III)4
Physiological functions Determines subthreshold excitability of neurons
Mutations and pathophysiology A number of allelic variants have been identified
Pharmacological significance Anticonvulsants (activators)
  • aa, amino acids; chr., chromosome; XE991, 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one; BMS204352, 3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-indol-2- one.

  • 1. Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, and Steinmeyer K (2000) Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity. J Biol Chem 275:22395-22400

  • 2. Wickenden AD, Zou A, Wagoner PK, and Jegla T (2001) Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. Br J Pharmacol 132:381-384

  • 3. Dupuis DS, Schroder RL, Jespersen T, Christensen JK, Christophersen P, Jensen BS, and Olesen SP (2002) Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352. Eur J Pharmacol 437:129-137

  • 4. Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, and Jentsch TJ (2000) KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J Biol Chem 275:24089-24095