Channel name | KV8.11,2,3 |
Description | Modifier/silencer |
Other names | Kv2.3, HNKA |
Molecular information | Human: 500aa, NM_014379, chr. 8q22.3-24.1, KCNV1, GeneID: 27012, PMID: 6708331 |
Mouse: 503aa, NM_026200, chr. 15 | |
Rat: 503aa, NM_021697, chr. 7q31 | |
Associated subunits | Coassembles with KV2 family channels |
Functional assays | Voltage-clamp |
Current | None established |
Conductance | Not functional on its own |
Ion selectivity | Not functional on its own |
Activation | Not functional on its own |
Inactivation | Not functional on its own |
Activators | None |
Gating inhibitors | None |
Blockers | None |
Radioligands | None |
Channel distribution | Infant brain, adult brain (layers II, IV, and VI of the cerebral cortex, hippocampus, CA1—CA4 pyramidal cell layer, granule cells of the dentate gyrus, granule cell layer, Purkinje cell layer of the cerebellum), kidney |
Physiological functions | Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium current; modulates the activity of KV2.1 and KV2.2 channels by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarized values |
Mutations and pathophysiology | Not established |
Pharmacological significance | Not established |
Comments | KV8.1 has no function on its own, but it has important modulatory actions on KV2 channels |
aa, amino acids; chr., chromosome.
↵1. Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattei MG, and Lazdunski M (1996) Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. EMBO J 15:3322-3331
↵2. Salinas M, de Weille J, Guillemare E, Lazdunski M, and Hugnot JP (1997) Modes of regulation of Shab K+ channel activity by the Kv8.1 subunit. J Biol Chem 272:8774-8780
↵3. Chiara MD, Monje F, Castellano A, and Lopez-Barneo J (1999) A small domain in the N terminus of the regulatory α-subunit Kv2.3 modulates Kv2.1 potassium channel gating. J Neurosci 19:6865-6873