TABLE 29

KV8.1 channels

Channel name KV8.11,2,3
Description Modifier/silencer
Other names Kv2.3, HNKA
Molecular information Human: 500aa, NM_014379, chr. 8q22.3-24.1, KCNV1, GeneID: 27012, PMID: 6708331
Mouse: 503aa, NM_026200, chr. 15
Rat: 503aa, NM_021697, chr. 7q31
Associated subunits Coassembles with KV2 family channels
Functional assays Voltage-clamp
Current None established
Conductance Not functional on its own
Ion selectivity Not functional on its own
Activation Not functional on its own
Inactivation Not functional on its own
Activators None
Gating inhibitors None
Blockers None
Radioligands None
Channel distribution Infant brain, adult brain (layers II, IV, and VI of the cerebral cortex, hippocampus, CA1—CA4 pyramidal cell layer, granule cells of the dentate gyrus, granule cell layer, Purkinje cell layer of the cerebellum), kidney
Physiological functions Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium current; modulates the activity of KV2.1 and KV2.2 channels by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarized values
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments KV8.1 has no function on its own, but it has important modulatory actions on KV2 channels
  • aa, amino acids; chr., chromosome.

  • 1. Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattei MG, and Lazdunski M (1996) Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. EMBO J 15:3322-3331

  • 2. Salinas M, de Weille J, Guillemare E, Lazdunski M, and Hugnot JP (1997) Modes of regulation of Shab K+ channel activity by the Kv8.1 subunit. J Biol Chem 272:8774-8780

  • 3. Chiara MD, Monje F, Castellano A, and Lopez-Barneo J (1999) A small domain in the N terminus of the regulatory α-subunit Kv2.3 modulates Kv2.1 potassium channel gating. J Neurosci 19:6865-6873