KV8.2 channels

Channel name KV8.2
Description Modifier/silencer
Other names Kv11.11
Molecular information Human: 545aa, NM_133497, chr. 9p24.2, KCNV2, GeneID: 169522, PMID: 120607451
Mouse: 562aa, NM_183179, chr. 19
Rat: 561 aa, XM_220024 (predicted), chr. 1
Associated subunits Coassembles with KV2 family channels
Functional assays Voltage-clamp
Current None established
Conductance Not functional on its own
Ion selectivity Not functional on its own
Activation Not functional on its own
Inactivation Not functional on its own
Activators None
Gating inhibitors None
Blockers None
Radioligands None
Channel distribution Lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon1
Physiological functions Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium currents; modulates the activity of KV2.1 channels by causing small changes in activation threshold and kinetics and in C-type inactivation1
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments KV8.2 has no function on its own, but it has important modulatory actions on KV2 channels
  • aa, amino acids; chr., chromosome.

  • 1. Ottschytsch N, Raes A, Van Hoorick D, and Snyders DJ (2002) Obligatory heterotetramerization of three previously uncharacterized Kv channel-subunits identified in the human genome. Proc Natl Acad Sci USA 99:7986-7991