KV8.2 channels
| Channel name | KV8.2 |
| Description | Modifier/silencer |
| Other names | Kv11.11 |
| Molecular information | Human: 545aa, NM_133497, chr. 9p24.2, KCNV2, GeneID: 169522, PMID: 120607451 |
| Mouse: 562aa, NM_183179, chr. 19 | |
| Rat: 561 aa, XM_220024 (predicted), chr. 1 | |
| Associated subunits | Coassembles with KV2 family channels |
| Functional assays | Voltage-clamp |
| Current | None established |
| Conductance | Not functional on its own |
| Ion selectivity | Not functional on its own |
| Activation | Not functional on its own |
| Inactivation | Not functional on its own |
| Activators | None |
| Gating inhibitors | None |
| Blockers | None |
| Radioligands | None |
| Channel distribution | Lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon1 |
| Physiological functions | Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium currents; modulates the activity of KV2.1 channels by causing small changes in activation threshold and kinetics and in C-type inactivation1 |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | KV8.2 has no function on its own, but it has important modulatory actions on KV2 channels |
aa, amino acids; chr., chromosome.
↵1. Ottschytsch N, Raes A, Van Hoorick D, and Snyders DJ (2002) Obligatory heterotetramerization of three previously uncharacterized Kv channel-subunits identified in the human genome. Proc Natl Acad Sci USA 99:7986-7991