KV9.1 channels
| Channel name | KV9.11,2,3,4 |
| Description | Modifier/silencer |
| Other names | None |
| Molecular information | Human: 526 aa, NM_002251, chr. 20q12, KCNS1, GeneID: 3787, PMID: 104843283 |
| Mouse: 497 aa, NM_008435, chr. 2 | |
| Rat: 497 aa, NM_053954, chr. 3q42 | |
| Associated subunits | Coassembles with KV2 family channels |
| Functional assays | Voltage-clamp |
| Current | None established |
| Conductance | Not functional on its own |
| Ion selectivity | Not functional on its own |
| Activation | Not functional on its own |
| Inactivation | Not functional on its own |
| Activators | None |
| Gating inhibitors | None |
| Blockers | None |
| Radioligands | None |
| Channel distribution | Infant brain, adult brain (frontal cortex), lens epithelium, melanocytes (in mouse brain, the distribution of KV9.1 is similar to KV9.2, with highest expression levels in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei, and cerebellum; KV9.1 and KV9.2 are colocalized with KV2.1 and/or KV2.2 α subunits in several regions) |
| Physiological functions | Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium current; modulates the activity of KV2.1 and KV2.2 α subunits by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarised values; KV9.1 enhances the single-channel conductance of KV2.1 |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | The human KV9.1 gene is composed of a minimum of 5 exons, with at least 2 alternatively spliced exons in the 5′-untranslated region3 |
aa, amino acids; chr., chromosome.
↵1. Salinas M, Duprat F, Heurteaux C, Hugnot JP, and Lazdunski M (1997) New modulatory α subunits for mammalian Shab K+ channels. J Biol Chem 272:24371-24379
↵2. Stocker M and Kerschensteiner D (1998) Cloning and tissue distribution of two new potassium channel α-subunits from rat brain. Biochem Biophys Res Commun 248:927-934
↵3. Shepard AR and Rae JL (1999) Electrically silent potassium channel subunits from human lens epithelium. Am J Physiol 277:C412-C424
↵4. Richardson FC and Kaczmarek LK (2000) Modification of delayed rectifier potassium currents by the Kv9.1 potassium channel subunit. Hear Res 147:21-30