KV9.2 channels

Channel name KV9.21,2
Description Modifier/silencer
Other names None
Molecular information Human: 477aa, NM_020697, chr. 8q22,3 KCNS2, GeneID: 3788, PMID: 93058951
Mouse: 477aa, NM_181317, chr. 15
Rat: 477 aa, NM_023966, chr. 7q22
Associated subunits Coassembles with KV2 family channels
Functional assays Voltage-clamp
Current None established
Conductance Not functional on its own
Ion selectivity Not functional on its own
Activation Not functional on its own
Inactivation Not functional on its own
Activators None
Gating inhibitors None
Blockers None
Radioligands None
Channel distribution Infant and adult brain, retina, spinal cord (in mouse brain, the distribution of KV9.2 is similar to KV9.1, with highest expression levels in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei, and cerebellum; KV9.1 and KV9.2 are colocalized with KV2.1 and/or KV2.2 α subunits in several regions; also found in the retina, spinal cord, and pulmonary artery)
Physiological functions Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium current; modulates the activity of KV2.1 and KV2.2 α subunits by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarized values; KV9.1 enhances the single-channel conductance of KV2.1
Mutations and pathophysiology Not established
Pharmacological significance Not established
  • aa, amino acids; chr., chromosome.

  • 1. Salinas M, Duprat F, Heurteaux C, Hugnot JP, and Lazdunski M (1997) New modulatory α subunits for mammalian Shab K+ channels. J Biol Chem 272:24371-24379

  • 2. Davies AR and Kozlowski RZ (2001) Kv channel subunit expression in rat pulmonary arteries. Lung 179:147-161

  • 3. Banfi S, Borsani G, Rossi E, Bernard L, Guffanti A, Rubboli F, Marchitiello A, Giglio S, Coluccia E, Zollo M, et al. (1996) Identification and mapping of human cDNAs homologous to Drosophila mutant genes through EST database searching. Nat Genet 13:167-174