KV9.3 channels
| Channel name | KV9.31,2,3 |
| Description | Modifier/silencer |
| Other names | None |
| Molecular information | Human: 491aa, NM_023966, NM_002252, chr. 2p24, KCNS3 (see `Comments'), GeneID: 3790, PMID: 93624761 |
| Mouse: 491aa, NM_173417, chr. 12 | |
| Rat: 491aa, NM_031778, chr. 6q14 | |
| Associated subunits | Coassembles with KV2 family channels |
| Functional assays | Voltage-clamp |
| Current | KV9.3/KV2.1 and ATP-dependent delayed rectifier channel in oxygen-sensitive pulmonary myocytes |
| Conductance | Not functional on its own |
| Ion selectivity | Not functional on its own |
| Activation | Not functional on its own |
| Inactivation | KV9.3/KV2.1 heteromers inactivate in a fast and complete fashion from intermediate closed states but in a slow and incomplete manner from open states4 |
| Activators | None |
| Gating inhibitors | None |
| Blockers | Hypoxia blocks KV9.3/KV2.1 channels5 |
| Radioligands | None |
| Channel distribution | Brain, breast, colon, eye, lens, heart, kidney, muscle, lung, testis, skin, stomach, uterus6; also found in lens epithelium3 |
| Physiological functions | Regulation of membrane potential in pulmonary artery myocytes |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Pulmonary artery hypertension |
| Comments | The human KV9.3 gene is intronless across the coding region 3′-UTR and all of the analysed 5′-UTR |
aa, amino acids; chr., chromosome; UTR, untranslated region.
↵1. Patel AJ, Lazdunski M, and Honore E (1997) Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes. EMBO J 16:6615-6625
↵2. Stocker M and Kerschensteiner D (1998) Cloning and tissue distribution of two new potassium channel α-subunits from rat brain. Biochem Biophys Res Commun 248:927-934
↵3. Shepard AR and Raem JL (1999) Electrically silent potassium channel subunits from human lens epithelium. Am J Physiol 277, C412-C424
↵4. Kerschensteiner D and Stocker M (1999) Heteromeric assembly of Kv2.1 with Kv9.3: effect on the state dependence of inactivation. Biophys J 77:248-257
↵5. Hulme JT, Coppock EA, Felipe A, Martens JR, and Tamkun MM (1999) Oxygen sensitivity of cloned voltage-gated K+ channels expressed in the pulmonary vasculature. Circ Res 85:489-497
↵6. UniGeneCluster Hs0.47584; OMIM no. 603888