KV11.3 channels

Channel name KV11.3
Description Voltage-gated potassium channel
Other names erg31,2,3
Molecular information Human: 1196aa, NM_033272 (transcript variant 1), chr. 2q24.2, KCNH7, GeneID: 90134, PMID: 104143059
Mouse: 1195aa, NM_133207, chr. 2
Rat: 1195aa, NM_131912, chr. 3q21
Associated subunits See “Comments”
Functional assays Voltage-clamp
Current Not established
Conductance Not established
Ion selectivity K2+
Activation Activated at –50 mV2 (see “Comments”)
Inactivation Not established
Activators None
Gating inhibitors None
Blockers Sertindole (43 nM)2 and pimozide (103 nM)2
Radioligands None
Channel distribution Brain, sympathetic ganglia, CA pyramidal neurons,4 lactotrophs,5 GH3/B6 cells, rat pituitary6
Physiological functions Not established
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments Thyrotropin-releasing hormone reduces KV11.3 currents and shifts the voltage dependence of activation by 6 mV7; KV11.1, KV11.2, and KV11.3 can form heteromultimers8
  • aa, amino acids; chr., chromosome.

  • 1. Shi W, Wymore RS, Wang HS, Pan Z, Cohen IS, McKinnon D, and Dixon JE (1997) Identification of two nervous system-specific members of the erg potassium channel gene family. J Neurosci 17:9423-9432

  • 2. Kang J, Chen XL, and Rampe D (2001) The antipsychotic drugs sertindole and pimozide block erg3, a human brain K+ channel. Biochem Biophys Res Commun 286:499-504

  • 3. Ganetzky BS and Titus SA (2000) inventors, Wisconsin Alumni Research Foundation, assignee. Potassium ion channel genes and proteins. U.S. patent A6,087,488. 2000 11 Jul

  • 4. Saganich MJ, Machado E, and Rudy B (2001) Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain. J Neurosci 21:4609-4624

  • 5. Schafer R, Wulfsen I, Behrens S, Weinsberg F, Bauer CK, and Schwarz JR (1999) The erg-like potassium current in rat lactotrophs. J Physiol 518:401-416

  • 6. Wulfsen I, Hauber HP, Schiemann D, Bauer CK, and Schwarz JR (2000) Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary. J. Neuroendocrinol 12:263-272

  • 7. Schledermann W, Wulfsen I, Schwarz JR, and Bauer CK (2001) Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade. J Physiol 532:143-163

  • 8. Wimmers S, Wulfsen I, Bauer CK, and Schwarz JR (2001) Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers. Pflueg Arch Eur J Physiol 441:450-455

  • 9. Ganetzky B, Robertson GA, Wilson GF, Trudeau MC, and Titus SA (1999) The eag family of K+ channels in Drosophila and mammals. Ann NY Acad Sci 868:356-369