KV11.3 channels
| Channel name | KV11.3 |
| Description | Voltage-gated potassium channel |
| Other names | erg31,2,3 |
| Molecular information | Human: 1196aa, NM_033272 (transcript variant 1), chr. 2q24.2, KCNH7, GeneID: 90134, PMID: 104143059 |
| Mouse: 1195aa, NM_133207, chr. 2 | |
| Rat: 1195aa, NM_131912, chr. 3q21 | |
| Associated subunits | See “Comments” |
| Functional assays | Voltage-clamp |
| Current | Not established |
| Conductance | Not established |
| Ion selectivity | K2+ |
| Activation | Activated at –50 mV2 (see “Comments”) |
| Inactivation | Not established |
| Activators | None |
| Gating inhibitors | None |
| Blockers | Sertindole (43 nM)2 and pimozide (103 nM)2 |
| Radioligands | None |
| Channel distribution | Brain, sympathetic ganglia, CA pyramidal neurons,4 lactotrophs,5 GH3/B6 cells, rat pituitary6 |
| Physiological functions | Not established |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | Thyrotropin-releasing hormone reduces KV11.3 currents and shifts the voltage dependence of activation by 6 mV7; KV11.1, KV11.2, and KV11.3 can form heteromultimers8 |
aa, amino acids; chr., chromosome.
↵1. Shi W, Wymore RS, Wang HS, Pan Z, Cohen IS, McKinnon D, and Dixon JE (1997) Identification of two nervous system-specific members of the erg potassium channel gene family. J Neurosci 17:9423-9432
↵2. Kang J, Chen XL, and Rampe D (2001) The antipsychotic drugs sertindole and pimozide block erg3, a human brain K+ channel. Biochem Biophys Res Commun 286:499-504
↵3. Ganetzky BS and Titus SA (2000) inventors, Wisconsin Alumni Research Foundation, assignee. Potassium ion channel genes and proteins. U.S. patent A6,087,488. 2000 11 Jul
↵4. Saganich MJ, Machado E, and Rudy B (2001) Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain. J Neurosci 21:4609-4624
↵5. Schafer R, Wulfsen I, Behrens S, Weinsberg F, Bauer CK, and Schwarz JR (1999) The erg-like potassium current in rat lactotrophs. J Physiol 518:401-416
↵6. Wulfsen I, Hauber HP, Schiemann D, Bauer CK, and Schwarz JR (2000) Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary. J. Neuroendocrinol 12:263-272
↵7. Schledermann W, Wulfsen I, Schwarz JR, and Bauer CK (2001) Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade. J Physiol 532:143-163
↵8. Wimmers S, Wulfsen I, Bauer CK, and Schwarz JR (2001) Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers. Pflueg Arch Eur J Physiol 441:450-455
↵9. Ganetzky B, Robertson GA, Wilson GF, Trudeau MC, and Titus SA (1999) The eag family of K+ channels in Drosophila and mammals. Ann NY Acad Sci 868:356-369