KV12.1 channels

Channel name KV12.1
Description Slowly activating and deactivating voltage-gated potassium channel1
Other names elk1,1 elk32
Molecular information Human: 1107aa, NM_144633, chr. 3p24.3, KCNH8, GeneID: 131096, PMID: 128906473
Mouse: 1102aa, NM_001031811, chr. 17
Rat: 1102aa, NM_145095, chr. 9q11 (see “Comments”)
Associated subunits Not established
Functional assays Voltage-clamp
Current None identified
Conductance Not established
Ion selectivity K+
Activation Not established
Inactivation Not established
Activators None
Gating inhibitors None
Blockers Ba2+ 1
Radioligands None
Channel distribution Sympathetic ganglia, testis, brain, colon, lung, uterus, pre-B cell leukemia (ESTs)1,2
Physiological functions Not established
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments There is a light oxygen voltage (LOV) and cyclic nucleotide binding (CNB) domain in the N and C terminus, respectively.
  • aa, amino acids; chr., chromosome.

  • 1. Shi W, Wang HS, Pan Z, Wymore RS, Cohen IS, McKinnon D, and Dixon JE (1998) Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia J Physiol 511:675-682

  • 2. Engeland B, Neu A, Ludwig J, Roeper J, and Pongs O (1998) Cloning and functional expression of rat ether-à-go-go-like K+ channel genes. J Physiol 513:647-654

  • 3. Zou A, Lin Z, Humble M, Creech CD, Wagoner PK, Krafte D, Jegla TJ, and Wickenden AD (2003) Distribution and functional properties of human KCNH8 (Elk1) potassium channels. Am J Physiol Cell Physiol 285:C1356-C1366