KV12.1 channels
| Channel name | KV12.1 |
| Description | Slowly activating and deactivating voltage-gated potassium channel1 |
| Other names | elk1,1 elk32 |
| Molecular information | Human: 1107aa, NM_144633, chr. 3p24.3, KCNH8, GeneID: 131096, PMID: 128906473 |
| Mouse: 1102aa, NM_001031811, chr. 17 | |
| Rat: 1102aa, NM_145095, chr. 9q11 (see “Comments”) | |
| Associated subunits | Not established |
| Functional assays | Voltage-clamp |
| Current | None identified |
| Conductance | Not established |
| Ion selectivity | K+ |
| Activation | Not established |
| Inactivation | Not established |
| Activators | None |
| Gating inhibitors | None |
| Blockers | Ba2+ 1 |
| Radioligands | None |
| Channel distribution | Sympathetic ganglia, testis, brain, colon, lung, uterus, pre-B cell leukemia (ESTs)1,2 |
| Physiological functions | Not established |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | There is a light oxygen voltage (LOV) and cyclic nucleotide binding (CNB) domain in the N and C terminus, respectively. |
aa, amino acids; chr., chromosome.
↵1. Shi W, Wang HS, Pan Z, Wymore RS, Cohen IS, McKinnon D, and Dixon JE (1998) Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia J Physiol 511:675-682
↵2. Engeland B, Neu A, Ludwig J, Roeper J, and Pongs O (1998) Cloning and functional expression of rat ether-à-go-go-like K+ channel genes. J Physiol 513:647-654
↵3. Zou A, Lin Z, Humble M, Creech CD, Wagoner PK, Krafte D, Jegla TJ, and Wickenden AD (2003) Distribution and functional properties of human KCNH8 (Elk1) potassium channels. Am J Physiol Cell Physiol 285:C1356-C1366