KV12.2 channels

Channel name KV12.2
Description Voltage-gated potassium channel
Other names BEC1,1 Elk22
Molecular information Human: 1083aa, NM_012284, chr. 12q13,1 KCNH3, GeneID: 23416, PMID: 104551801
Mouse: 1095aa, NM_010601, chr. 15
Rat: 1087aa, NM_017108, 7q36
Associated subunits None determined
Functional assays Voltage-clamp
Current Not established
Conductance Not established
Ion selectivity K+
Activation Not established
Inactivation Fast1,2
Activators None
Gating inhibitors None
Blockers None
Radioligands None
Channel distribution Infant brain, lung (small cell carcinoma), eye (retinoblastoma), sciatic nerve, cortex, amygdala, hippocampus (mainly in CA1 and CA3 pyramidal cell body layers and in the granule cell layers of the dentate gyrus); in the striatal regions, including the putamen and caudate nucleus, lymphocytes, leukemias, and NG108-15 cell line1,2,3,4,5
Physiological functions Not established
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments There is a light oxygen voltage (LOV) and cyclic nucleotide binding (CNB) domain in the N and C terminus, respectively.
  • aa, amino acids; chr., chromosome.

  • 1. Miyake A, Mochizuki S, Yokoi H, Kohda M, and Furuichi K (1999) New ether-à-go-go K+ channel family members localized in human telencephalon. J Biol Chem 274:25018-25025

  • 2. Engeland B, Neu A, Ludwig J, Roeper J, and Pongs O (1998) Cloning and functional expression of rat ether-à-go-go-like K+ channel genes. J Physiol 513:647-654

  • 3. Meves H, Schwarz JR, and Wulfsen I (1999) Separation of M-like current and ERG current in NG108–15 cells. Br J Pharmacol 127:1213-1223

  • 4. Saganich MJ, Machado E, and Rudy B (2001) Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain. J Neurosci 21:4609-4624

  • 5. Smith GA, Tsui HW, Newell EW, Jiang X, Zhu XP, Tsui FW, and Schlichter LC (2002) Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells. J Biol Chem 277:18528-18534