TABLE 41

KV12.3 channels

Channel name KV12.3
Description Slowly activating voltage-gated potassium channel
Other names BEC2,1 elk12
Molecular information Human: 1017aa, NM_012285, KCNH4, chr. 17q21.2, GeneID: 23415, PMID: 104551801
Rat: 1017aa, NM_053630, chr. 10q32.1 (see “Comments”)
Associated subunits None
Functional assays Voltage-clamp
Current Not established
Conductance Not established
Ion Selectivity K+
Activation Threshold for activation is 90 mV2
Inactivation Not established
Activators None
Gating inhibitors None
Blockers Ba2+ 2
Radioligands None
Channel distribution Brain (telencephalon),1,3 neuroblastoma, esophagus, oligodendroglioma, lung, primary B-cell neoplasia, cerebellum, pituitary gland4
Physiological functions Not established
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments There are light oxygen voltage (LOV) and cyclic nucleotide binding (CNB) domains in the N and C terminus, respectively.
  • aa, amino acids; chr., chromosome.

  • 1. Miyake A, Mochizuki S, Yokoi H, Kohda M, and Furuichi K (1999) New ether-à-go-go K+ channel family members localized inhuman telencephalon. J Biol Chem 274:25018-25025

  • 2. Engeland B, Neu A, Ludwig J, Roeper J, and Pongs O (1998) Cloning and functional expression of rat ether-à-go-go-like K+ channel genes. J Physiol 513:647-654

  • 3. Saganich MJ, Machado E, and Rudy B (2001) Differential expression of genes encoding sub threshold-operating voltage-gated K+ channels in brain. J Neurosci 21:4609-4624

  • 4. Wulfsen I, Hauber HP, Schiemann D, Bauer CK, and Schwarz JR (2000) Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary. J Neuroendocrinol 12:263-272